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<blockquote data-quote="Rand McClain DO" data-source="post: 111896" data-attributes="member: 90"><p>Hi eudes,</p><p>There is no contraindication taking dutasteride with anastrozole (Arimidex). You may indeed get better results with dutasteride than finasteride. Gynecomastia is not driven by DHT but rather estrogen. If you take a 5-alpha reductase inhibitor such as finasteride or dutasteride and you begin to get gynecomastia (assuming no other changes to your protocol), then the presumption is that while less T is being converted to DHT, that very same T, if you will, is now available to be, and is being, converted to estrogen. This is the only "interaction" between the use of either of these meds - ie, their effect on the substrate, T, from which they, DHT and estrogen, are made. Long-term tamoxifen safe? Safer than having estrogen activity too high, but there are studies showing tamoxifen is carcinogenic (not well publicized I believe because for someone with estrogen sensitive cancer it can be a life saver, and that hurdle needs to be crossed with tamoxifen sometimes being the only practical option). I prefer use of either an AI like anastrozole or a suicide inhibitor of estrogen like exemestane (Aromasin). To me, these two are for medical/clinical purposes essentially interchangeable, but exesmestane is usually more expensive.</p></blockquote><p></p>
[QUOTE="Rand McClain DO, post: 111896, member: 90"] Hi eudes, There is no contraindication taking dutasteride with anastrozole (Arimidex). You may indeed get better results with dutasteride than finasteride. Gynecomastia is not driven by DHT but rather estrogen. If you take a 5-alpha reductase inhibitor such as finasteride or dutasteride and you begin to get gynecomastia (assuming no other changes to your protocol), then the presumption is that while less T is being converted to DHT, that very same T, if you will, is now available to be, and is being, converted to estrogen. This is the only "interaction" between the use of either of these meds - ie, their effect on the substrate, T, from which they, DHT and estrogen, are made. Long-term tamoxifen safe? Safer than having estrogen activity too high, but there are studies showing tamoxifen is carcinogenic (not well publicized I believe because for someone with estrogen sensitive cancer it can be a life saver, and that hurdle needs to be crossed with tamoxifen sometimes being the only practical option). I prefer use of either an AI like anastrozole or a suicide inhibitor of estrogen like exemestane (Aromasin). To me, these two are for medical/clinical purposes essentially interchangeable, but exesmestane is usually more expensive. [/QUOTE]
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