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<blockquote data-quote="Marco N Cognito" data-source="post: 79667" data-attributes="member: 13"><p>Hello again, Dr. Ullis. We had some previous email exchanges back in 2010. Good to see you on Nelson's forum.</p><p></p><p>I am hypothyroid and am currently treating with 1 grain dessicated thyroid and just added 25mcg Tirosint. I do not have any autoimmune issues (i.e. Hashi's).</p><p></p><p>I recently started L-carnitine (in various forms) to help support cardiovascular health and r-ALA (r-alpha lipoic acid) to help support glutathione levels and to help improve insulin sensitivity. The carnitine not only helped my CV issues, but my stamina, endurance and strength have improved as well. </p><p></p><p>The concern I have is with respect to well-documented research which shows that exogenous carnitine elicits suppressive effects on thyroid metabolism, specifically inhibiting T3 and T4 entry into the cell nuclei:</p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/15591013" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/15591013</a></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/11201848" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/11201848</a> </p><p></p><p>And that ALA inhibits T4 to T3 conversion: <a href="https://www.ncbi.nlm.nih.gov/pubmed/1815532" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/1815532</a></p><p></p><p>Ironically, L-carnitine has been used to treat hypothyroid-associated chronic fatigue:<a href="https://www.jstage.jst.go.jp/article/endocrj/63/10/63_EJ16-0109/_article" target="_blank">https://www.jstage.jst.go.jp/article/endocrj/63/10/63_EJ16-0109/_article</a></p><p>And ALA ameliorates endothelial dysfunction in hypothyroid patients: <a href="https://www.ncbi.nlm.nih.gov/pubmed/20162509" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/20162509</a></p><p></p><p>This is obviously a conundrum for anyone who is borderline hypothyroid or worse but that has benefited from taking either. </p><p></p><p>Any thoughts as to how I can effectively balance the benefits of L-carnitine and ALA without exacerbating my thyroid function?</p></blockquote><p></p>
[QUOTE="Marco N Cognito, post: 79667, member: 13"] Hello again, Dr. Ullis. We had some previous email exchanges back in 2010. Good to see you on Nelson's forum. I am hypothyroid and am currently treating with 1 grain dessicated thyroid and just added 25mcg Tirosint. I do not have any autoimmune issues (i.e. Hashi's). I recently started L-carnitine (in various forms) to help support cardiovascular health and r-ALA (r-alpha lipoic acid) to help support glutathione levels and to help improve insulin sensitivity. The carnitine not only helped my CV issues, but my stamina, endurance and strength have improved as well. The concern I have is with respect to well-documented research which shows that exogenous carnitine elicits suppressive effects on thyroid metabolism, specifically inhibiting T3 and T4 entry into the cell nuclei: [URL]https://www.ncbi.nlm.nih.gov/pubmed/15591013[/URL] [URL]https://www.ncbi.nlm.nih.gov/pubmed/11201848[/URL] And that ALA inhibits T4 to T3 conversion: [URL]https://www.ncbi.nlm.nih.gov/pubmed/1815532[/URL] Ironically, L-carnitine has been used to treat hypothyroid-associated chronic fatigue:[url]https://www.jstage.jst.go.jp/article/endocrj/63/10/63_EJ16-0109/_article[/url] And ALA ameliorates endothelial dysfunction in hypothyroid patients: [URL]https://www.ncbi.nlm.nih.gov/pubmed/20162509[/URL] This is obviously a conundrum for anyone who is borderline hypothyroid or worse but that has benefited from taking either. Any thoughts as to how I can effectively balance the benefits of L-carnitine and ALA without exacerbating my thyroid function? [/QUOTE]
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