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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Aromatase inhibitors other than arimidex?
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<blockquote data-quote="Nelson Vergel" data-source="post: 4544" data-attributes="member: 3"><p>Aromasin (exemestane) stays in the body for a shorter time than anastrozole and needs to be given daily. Unlike anastrozole, it is an androgen-like molecule that can have some of the side effects of anabolic steroids. You can see below the molecules of the three most commonly used aromatase inhibitors used in breast cancer:</p><p>[ATTACH]467[/ATTACH]</p><p>Now, look at how similar exemestane looks like dehydrotestosterone (DHT), a metabolite of testosterone that is responsible for some of its androgenic effects:</p><p></p><p>[ATTACH]468[/ATTACH]</p><p></p><p></p><p>There is published study on the use of Aromasin and testosterone replacement.<a href="http://www.ncbi.nlm.nih.gov/pubmed/14671195" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/14671195</a></p><p></p><p>The following table was taken from a review paper comparing the latest 3 AIs in the treatment of breast cancer. It shows that at the high doses used for breast cancer, exemestane is a weaker blocker of estradiol. I am not completely sure that is a bad thing since excessive estradiol decreases can be a bad thing for men's sexual and brain function and body composition as reported in some older studies.</p><p>[ATTACH]465[/ATTACH]</p><p>Source:<a href="http://onlinelibrary.wiley.com/doi/10.1002/cncr.10908/full" target="_blank">http://onlinelibrary.wiley.com/doi/10.1002/cncr.10908/full</a></p><p></p><p>The following table shows how exemestane can lower high density lipoprotein (HDL- the "good" cholesterol) and triglycerides much like anabolic steroids (and DHT) do.</p><p></p><p>[ATTACH]466[/ATTACH]</p><p></p><p></p><p>Like oral androgen products, exemestane may also increase liver enzymes:<a href="http://livertox.nih.gov/Exemestane.htm" target="_blank">http://livertox.nih.gov/Exemestane.htm</a></p><p></p><p>Like oral androgen-like products, it has also been reported to improve lean mass in women treated for breast cancer: <a href="http://www.ergo-log.com/exemestane.html" target="_blank">http://www.ergo-log.com/exemestane.html</a></p><p></p><p></p><p>Some bodybuilding forums speculate that Aromasin is better than anastrozole since it completely deactivates the estrogen receptors. The table above does not support that statement. However, I am curious to see sexual function data comparing TRT plus anastrozole or exemestane to see if the androgen-like nature of exemestane makes a difference at all. However, the HDL and liver enzyme issues make me worry.</p><p></p><p>I welcome a study using 12.5-25 mg per day of exemestane versus 0.5-1 mg per week of anastrozole in men on testosterone replacement with estradiol (by ultrasensitive testing) over 35 pg/ml to see the effects on not only estradiol but on the liver, HDL cholesterol, bone density, sexual function and body composition. We may never see a study like this one!</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 4544, member: 3"] Aromasin (exemestane) stays in the body for a shorter time than anastrozole and needs to be given daily. Unlike anastrozole, it is an androgen-like molecule that can have some of the side effects of anabolic steroids. You can see below the molecules of the three most commonly used aromatase inhibitors used in breast cancer: [ATTACH=CONFIG]467[/ATTACH] Now, look at how similar exemestane looks like dehydrotestosterone (DHT), a metabolite of testosterone that is responsible for some of its androgenic effects: [ATTACH=CONFIG]468[/ATTACH] There is published study on the use of Aromasin and testosterone replacement.[URL]http://www.ncbi.nlm.nih.gov/pubmed/14671195[/URL] The following table was taken from a review paper comparing the latest 3 AIs in the treatment of breast cancer. It shows that at the high doses used for breast cancer, exemestane is a weaker blocker of estradiol. I am not completely sure that is a bad thing since excessive estradiol decreases can be a bad thing for men's sexual and brain function and body composition as reported in some older studies. [ATTACH=CONFIG]465[/ATTACH] Source:[URL]http://onlinelibrary.wiley.com/doi/10.1002/cncr.10908/full[/URL] The following table shows how exemestane can lower high density lipoprotein (HDL- the "good" cholesterol) and triglycerides much like anabolic steroids (and DHT) do. [ATTACH=CONFIG]466[/ATTACH] Like oral androgen products, exemestane may also increase liver enzymes:[URL]http://livertox.nih.gov/Exemestane.htm[/URL] Like oral androgen-like products, it has also been reported to improve lean mass in women treated for breast cancer: [URL]http://www.ergo-log.com/exemestane.html[/URL] Some bodybuilding forums speculate that Aromasin is better than anastrozole since it completely deactivates the estrogen receptors. The table above does not support that statement. However, I am curious to see sexual function data comparing TRT plus anastrozole or exemestane to see if the androgen-like nature of exemestane makes a difference at all. However, the HDL and liver enzyme issues make me worry. I welcome a study using 12.5-25 mg per day of exemestane versus 0.5-1 mg per week of anastrozole in men on testosterone replacement with estradiol (by ultrasensitive testing) over 35 pg/ml to see the effects on not only estradiol but on the liver, HDL cholesterol, bone density, sexual function and body composition. We may never see a study like this one! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Aromatase inhibitors other than arimidex?
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