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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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<blockquote data-quote="PhantomFear" data-source="post: 179911" data-attributes="member: 38928"><p>Anecdotally, I always got bone and joint pain when taking an ai.</p><p></p><p>I'm currently off TRT right now and my estradiol is rather low, yet I have zero joint pain. Here are what my last set of bloods looked like:</p><p></p><p>Testosterone: 18.2 nmol/L (500 ng/dL) (Range: 8.6 - 29 nmol/L)</p><p>Estradiol: 55 pmol/L (14 pg/ml) (Range: 45 - 159 pmol/L)</p><p>Progesterone: 1.4 nmol/L (0.44 ng/ml) (Range: < 0.474 nmol/L)</p><p></p><p>First off, the range for male progesterone is wrong.</p><p></p><p><a href="http://www.hormonebalance.org/images/documents/Oettel%2004%20Progesterone%20MEN%20AM_1313008091.pdf" target="_blank">Progesterone: the forgotten hormone in men?</a></p><p>"We analyzed serum samples from 1015 men aged 20–90 years and serum samples from 330 postmenopausal women aged 50–90 years by a radioimmunoassay for progesterone. We found 1.21+ 0.41 SD nmol/l (0.38+0.13 ng/ml) for men and 1.24+1.18 SD nmol/l (0.38+0.37 ng/ml) for women, i.e. there were no differences between men and women."</p><p></p><p>Despite being 3x above the 'healthy' range, my progesterone levels fall inline with most data that investigates male progesterone levels, with mine being considered high-normal. </p><p></p><p>My estradiol is objectively quite low, yet I have zero joint pain.</p><p></p><p>When I was on TRT + using an ai, I had very severe joint pain. Here are what my bloods looked like on trt, just before I came off for the second time:</p><p></p><p>Testosterone: 28.2 nmol/L (813 ng/dL) (Range: 8.6 - 29 nmol/L)</p><p>Estradiol: 150 pmol/L (40 pg/mL) (Range: 45 - 159 pmol/L)</p><p>Progesterone: < 0.141 nmol/L (Undetectable) (Range: < 0.474 nmol/L)</p><p></p><p>Higher estradiol, undetectable progesterone, and severe bone and joint pain. I'm not saying that ai alone caused my deficient progesterone, as I believe it is mostly a product of HPTA shutdown and impaired cholesterol -> preg. However, it is unsurprising that further reducing progesterone and the expression of it's receptor in a man who is already low causes undesirable effects. This is all whilst serum estraidol (not a good indicator of tissue status, I know) is at the top of the range.</p><p></p><p>Again, I understand that this is anecdotal, but it supports my previous claim and the studies I provided.</p></blockquote><p></p>
[QUOTE="PhantomFear, post: 179911, member: 38928"] Anecdotally, I always got bone and joint pain when taking an ai. I'm currently off TRT right now and my estradiol is rather low, yet I have zero joint pain. Here are what my last set of bloods looked like: Testosterone: 18.2 nmol/L (500 ng/dL) (Range: 8.6 - 29 nmol/L) Estradiol: 55 pmol/L (14 pg/ml) (Range: 45 - 159 pmol/L) Progesterone: 1.4 nmol/L (0.44 ng/ml) (Range: < 0.474 nmol/L) First off, the range for male progesterone is wrong. [URL='http://www.hormonebalance.org/images/documents/Oettel%2004%20Progesterone%20MEN%20AM_1313008091.pdf']Progesterone: the forgotten hormone in men?[/URL] "We analyzed serum samples from 1015 men aged 20–90 years and serum samples from 330 postmenopausal women aged 50–90 years by a radioimmunoassay for progesterone. We found 1.21+ 0.41 SD nmol/l (0.38+0.13 ng/ml) for men and 1.24+1.18 SD nmol/l (0.38+0.37 ng/ml) for women, i.e. there were no differences between men and women." Despite being 3x above the 'healthy' range, my progesterone levels fall inline with most data that investigates male progesterone levels, with mine being considered high-normal. My estradiol is objectively quite low, yet I have zero joint pain. When I was on TRT + using an ai, I had very severe joint pain. Here are what my bloods looked like on trt, just before I came off for the second time: Testosterone: 28.2 nmol/L (813 ng/dL) (Range: 8.6 - 29 nmol/L) Estradiol: 150 pmol/L (40 pg/mL) (Range: 45 - 159 pmol/L) Progesterone: < 0.141 nmol/L (Undetectable) (Range: < 0.474 nmol/L) Higher estradiol, undetectable progesterone, and severe bone and joint pain. I'm not saying that ai alone caused my deficient progesterone, as I believe it is mostly a product of HPTA shutdown and impaired cholesterol -> preg. However, it is unsurprising that further reducing progesterone and the expression of it's receptor in a man who is already low causes undesirable effects. This is all whilst serum estraidol (not a good indicator of tissue status, I know) is at the top of the range. Again, I understand that this is anecdotal, but it supports my previous claim and the studies I provided. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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