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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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<blockquote data-quote="PhantomFear" data-source="post: 179903" data-attributes="member: 38928"><p>First generation ai's do cause more supression of upstream hormone production, mainly because they inhibit the conversion of cholesterol -> preg, and thus the entire steroid hormone cascade. Third generation ai's don't have this effect, but they do seem to effect progesterone significantly.</p><p></p><p>Here are some papers that show reduced progesterone and/or progesterone receptor (PR) expression from the use of anastrozole:</p><p></p><p><a href="https://cancerres.aacrjournals.org/content/69/24_Supplement/2145" target="_blank">Anastrozole Reduces Progesterone and Proliferation Index in Short Term Hormone Therapy. A Prospective Placebo Double Blind Study.</a></p><p></p><p><a href="https://pubmed.ncbi.nlm.nih.gov/20886231/" target="_blank">Short-term Anastrozole Therapy Reduces Ki-67 and Progesterone Receptor Expression in Invasive Breast Cancer: A Prospective, Placebo-Controlled, Double-Blind Trial.</a></p><p></p><p><a href="https://www.intechopen.com/books/polycystic-ovarian-syndrome/effect-of-aromatase-inhibitors-versus-clomiphene-citrate-for-ovulation-induction-in-infertile-women-" target="_blank">Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO).</a></p><p></p><p>Also, here is a paper showing that Vitamin D alleviates aromatise inhibitor-induced bone pain:</p><p></p><p><a href="https://www.breastcancer.org/research-news/20091215-7" target="_blank">High-Dose Vitamin D May Ease Joint Pain from Arimidex.</a></p><p></p><p>Vitamin D has no estrogenic activity, but does activate the androgen and progesterone receptor. This, taken with the prior studies showing anastrozole reduces progesterone and the expression of it's receptor, suggest that the bone / joint pain (and perhaps many other ai-related sides) are from reduced progestenic activity - not from low estrogen. There are a few more studies that suggest the same thing, but these are the only ones I have to hand right now.</p><p></p><p>Almost every man I've seen test their progesterone on trt are deficient. I find it more likely that ai-related sides are from reducing already low progestenic activity, rather than slightly reducing an already high estradiol.</p></blockquote><p></p>
[QUOTE="PhantomFear, post: 179903, member: 38928"] First generation ai's do cause more supression of upstream hormone production, mainly because they inhibit the conversion of cholesterol -> preg, and thus the entire steroid hormone cascade. Third generation ai's don't have this effect, but they do seem to effect progesterone significantly. Here are some papers that show reduced progesterone and/or progesterone receptor (PR) expression from the use of anastrozole: [URL='https://cancerres.aacrjournals.org/content/69/24_Supplement/2145']Anastrozole Reduces Progesterone and Proliferation Index in Short Term Hormone Therapy. A Prospective Placebo Double Blind Study.[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/20886231/']Short-term Anastrozole Therapy Reduces Ki-67 and Progesterone Receptor Expression in Invasive Breast Cancer: A Prospective, Placebo-Controlled, Double-Blind Trial.[/URL] [URL='https://www.intechopen.com/books/polycystic-ovarian-syndrome/effect-of-aromatase-inhibitors-versus-clomiphene-citrate-for-ovulation-induction-in-infertile-women-']Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO).[/URL] Also, here is a paper showing that Vitamin D alleviates aromatise inhibitor-induced bone pain: [URL='https://www.breastcancer.org/research-news/20091215-7']High-Dose Vitamin D May Ease Joint Pain from Arimidex.[/URL] Vitamin D has no estrogenic activity, but does activate the androgen and progesterone receptor. This, taken with the prior studies showing anastrozole reduces progesterone and the expression of it's receptor, suggest that the bone / joint pain (and perhaps many other ai-related sides) are from reduced progestenic activity - not from low estrogen. There are a few more studies that suggest the same thing, but these are the only ones I have to hand right now. Almost every man I've seen test their progesterone on trt are deficient. I find it more likely that ai-related sides are from reducing already low progestenic activity, rather than slightly reducing an already high estradiol. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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