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I came across some interesting research about using high-dose Vitamin D (50,000 IUs a week) for the joint pain and bone loss associated with Arimidex.  These studies were looking at women who use AIs for breast cancer.  It was a while ago, but I seem to recall one of the studies showing that high dose Vitamin D increased aromatase activity specifically in the bones but not in the breast tissue.  They didn't investigate Vitamin D's effect on aromatase levels in other organs or tissues.  It raises an interesting question if high-dose Vitamin D ONLY targets aromatase in bones and joints but not elsewhere in the body.