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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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<blockquote data-quote="Cataceous" data-source="post: 178977" data-attributes="member: 38109"><p>The intention is ok, but the math is not. The rule of thumb is that you're close to steady-state after four to five half-lives. "Steady-state" in this case means each dosing cycle looks like the last, not that levels of the medication are constant. The problem with your example is that the dosing cycle of one week is 3.5 half-lives. With a two-day half-life the level from an initial dose has fallen to 9% of peak by the time for the second dose. Over time, contributions from doses other than the one before last are pretty negligible. So at peak you'll have 1.09 mg in your system right after each dose. If you run the math you find that 10 days after the initial dosing you'll have 0.39 mg in your system. Bottom line: if you want to see significant drug accumulation then the dose cycle length should be more like the half-life or less.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 178977, member: 38109"] The intention is ok, but the math is not. The rule of thumb is that you're close to steady-state after four to five half-lives. "Steady-state" in this case means each dosing cycle looks like the last, not that levels of the medication are constant. The problem with your example is that the dosing cycle of one week is 3.5 half-lives. With a two-day half-life the level from an initial dose has fallen to 9% of peak by the time for the second dose. Over time, contributions from doses other than the one before last are pretty negligible. So at peak you'll have 1.09 mg in your system right after each dose. If you run the math you find that 10 days after the initial dosing you'll have 0.39 mg in your system. Bottom line: if you want to see significant drug accumulation then the dose cycle length should be more like the half-life or less. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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