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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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<blockquote data-quote="Blackhawk" data-source="post: 178964" data-attributes="member: 16042"><p>First, i don't think you can mathematically calculate intended effect of a quartered dose. Very little in hormone therapy is proprtional or linear in this way.</p><p></p><p>Second, I think Vince Carter who was banned from this site was potentially on to something regarding low SHBG men and E2 (N=1). He was testing Free E2 and trying to pin down the relationships between frequency and amount of T dosing, AI variables and actual E2 blood levels rather than just speculating based on symptoms. You might want to search on his posts. I don't think this is a simple topic with simple guidelines for guys with low SHBG. He also switched to Aromasin since Anastrozole caused him endless problems. One of the takeaways, is you are shooting in the dark without (very) frequent labs to pin down actual levels. Everything is a moving target.</p><p></p><p>Third, trying to adjust dosage based solely on symptoms using 0.25 doses can be an exercise in futility. 0.25 can be fine for some, but a very hefty dose for others. When I was on anastrozole, my dose was 0.07mg EOD, for a total of less than 0.25/week, and I had high SHBG. It knocked my E2 down by ~10 points.</p><p></p><p>Fourth, it seems many guys have their libido, sensitivity etc perked up by changing hormone levels, and once steady state is reached, they decrease again, so it can be a moving target that you perk up then lose it again as body adjusts to new protocol. In this sense, sometimes a bit like chasing one's own tail.</p><p></p><p>Fifth, another aspect to this is the use of transdermals as replacement or adjunct to T cyp which can convert more to DHT rather than E2, and other T esters... many cans of worms to open.</p></blockquote><p></p>
[QUOTE="Blackhawk, post: 178964, member: 16042"] First, i don't think you can mathematically calculate intended effect of a quartered dose. Very little in hormone therapy is proprtional or linear in this way. Second, I think Vince Carter who was banned from this site was potentially on to something regarding low SHBG men and E2 (N=1). He was testing Free E2 and trying to pin down the relationships between frequency and amount of T dosing, AI variables and actual E2 blood levels rather than just speculating based on symptoms. You might want to search on his posts. I don't think this is a simple topic with simple guidelines for guys with low SHBG. He also switched to Aromasin since Anastrozole caused him endless problems. One of the takeaways, is you are shooting in the dark without (very) frequent labs to pin down actual levels. Everything is a moving target. Third, trying to adjust dosage based solely on symptoms using 0.25 doses can be an exercise in futility. 0.25 can be fine for some, but a very hefty dose for others. When I was on anastrozole, my dose was 0.07mg EOD, for a total of less than 0.25/week, and I had high SHBG. It knocked my E2 down by ~10 points. Fourth, it seems many guys have their libido, sensitivity etc perked up by changing hormone levels, and once steady state is reached, they decrease again, so it can be a moving target that you perk up then lose it again as body adjusts to new protocol. In this sense, sometimes a bit like chasing one's own tail. Fifth, another aspect to this is the use of transdermals as replacement or adjunct to T cyp which can convert more to DHT rather than E2, and other T esters... many cans of worms to open. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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