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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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<blockquote data-quote="DS3" data-source="post: 178961" data-attributes="member: 18514"><p>You’ll have [USER=3]@Nelson Vergel[/USER] and some others on here make a blanket statement that men don’t need to take Anastrozole because estrogen does not cause the negative symptoms that we believe are associated with elevated estrogen.</p><p></p><p>I can’t help but strongly believe this stance is more a reflection of inferring how they feel at higher levels of E2 (>50 pg/mL), as opposed to how most (or many) men on TRT feel at higher E2.</p><p></p><p>I can tell you my anecdote is very similar to yours. I am a low SHBG guy (for what it’s worth) and experience negative estrogenic symptoms at 50+pg/mL of estrogen. These symptoms disappear like clockwork after a 0.25 mg dose of Anastrozole. However, joint pain for me even at that dose is almost unbearable. Is this a result of crashing my E2? Nope. It tests at 40 pg/mL (from 55-60 pg/mL) within 48 hours of the dose.</p><p></p><p>My only explanation that I’ve been able to come up with that makes sense is that as you take an AI, you decrease aromatization at all Aromatase enzyme sites, including the skeletal system. Perhaps in some men the blocking of this enzyme in bone is stronger than in others and causes more joint pain. Doctors continue to blab on that this pain is only caused when men use excessive doses of an AI. This has not been the general consensus that I’ve seen on this forum, in myself, or other males I’ve talked to on TRT.</p></blockquote><p></p>
[QUOTE="DS3, post: 178961, member: 18514"] You’ll have [USER=3]@Nelson Vergel[/USER] and some others on here make a blanket statement that men don’t need to take Anastrozole because estrogen does not cause the negative symptoms that we believe are associated with elevated estrogen. I can’t help but strongly believe this stance is more a reflection of inferring how they feel at higher levels of E2 (>50 pg/mL), as opposed to how most (or many) men on TRT feel at higher E2. I can tell you my anecdote is very similar to yours. I am a low SHBG guy (for what it’s worth) and experience negative estrogenic symptoms at 50+pg/mL of estrogen. These symptoms disappear like clockwork after a 0.25 mg dose of Anastrozole. However, joint pain for me even at that dose is almost unbearable. Is this a result of crashing my E2? Nope. It tests at 40 pg/mL (from 55-60 pg/mL) within 48 hours of the dose. My only explanation that I’ve been able to come up with that makes sense is that as you take an AI, you decrease aromatization at all Aromatase enzyme sites, including the skeletal system. Perhaps in some men the blocking of this enzyme in bone is stronger than in others and causes more joint pain. Doctors continue to blab on that this pain is only caused when men use excessive doses of an AI. This has not been the general consensus that I’ve seen on this forum, in myself, or other males I’ve talked to on TRT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Arimidex - Pain Caused by Crashing E2 or Another Reason?
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