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That's been put out by one of our Drs and I'll not name him at risk of misquoting but yes, an AI is less effective in the testicular environment. Though I think and would assume in the best sense that we're talking about Anastrozole/Arimidex. I'm unsure if we could apply the same standard to one of the suicide inhibitors like Aromasin but I do attribute my change to Aromasin as something that did help me much better than Anastrozole has/did.