ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Are there any problems with having zero gonadotrophin?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 178644" data-attributes="member: 38109"><p>Some references below hinting at possible wider effects of LH. It's also not just the gonadotropins that are suppressed by TRT. Further upstream you have GnRH and kisspeptin, both of which may have additional functions.</p><p></p><p style="margin-left: 20px"><strong><em>Lei ZM, Rao CV, Kornyei JL, Licht P, Hiatt ES. Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. Endocrinology 1993;132(5):2262-70. </em></strong><em><a href="http://endo.endojournals.org/content/132/5/2262.abstract" target="_blank"><strong>Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain.</strong></a></em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>LH from anterior pituitary and hCG from placenta bind to a common receptor in gonadal and nongonadal reproductive tissues. There have been numerous examples suggesting that the brain may also contain hCG/LH receptors, yet there has been no evidence for their existence so far. We now demonstrate by reverse transcription-nested polymerase chain reaction and northern blotting that <strong>the rat brain contains hCG/LH receptor mRNA</strong>. ...</em></p> <p style="margin-left: 20px"></p><p>-----------</p><p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong><em>Yang E-J, Nasipak BT, Kelley DB. Direct action of gonadotropin in brain integrates behavioral and reproductive functions. Proceedings of the National Academy of Sciences 2007;104(7):2477-82. </em></strong><em><a href="http://www.pnas.org/content/104/7/2477.full.pdf+html" target="_blank"><strong>Direct action of gonadotropin in brain integrates behavioral and reproductive functions</strong></a></em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Essential roles for gonadotropins in gonadal development and reproduction are well established. Over the past decade, however, the expression of luteinizing hormone receptor (LHR) has also been reported in the brain of various mammals and birds. Although suggestive, it has not yet been determined whether this expression pattern supports a novel function for gonadotropins. Here, <strong>we demonstrate a CNS-mediated role of gonadotropins in a reproductive behavior</strong>: the courtship songs of the South African clawed frog, Xenopus laevis. Male advertisement calling in this species depends on a nongonadal action of gonadotropin. ...</em></p><p></p><p>-----------</p><p style="margin-left: 20px"><strong><em>Kokk K, Kuuslahti M, Keisala T, et al. Expression of LH Receptors in the Mouse Penis. J Androl:jandrol.109.008623. </em></strong><em><a href="http://www.andrologyjournal.org/cgi/content/abstract/jandrol.109.008623v1" target="_blank"><strong>Expression of LH Receptors in the Mouse Penis -- Kokk et al., 10.2164/jandrol.109.008623 -- Journal of Andrology</strong></a> </em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>The role of luteinizing hormone (LH) in the regulation of normal reproductive functions in males and females is quite well established. Besides the expression of LH receptors in the target cells in gonads, it has been found in several extragonadal organs. There is no information about the expression of LH receptors in the penis up to now. The aim of present study is to investigate the expression of LH receptor in the mouse penis to see if LH effects are possible in the penis. BALB/c mice were used as donors of normal penis and testis tissue. Immunocytochemistry, Western blotting and quantitative RT-PCR reactions were used for the detection of the LH receptor. Positive immunoreaction for LH receptors was present in the nuclei of urethral epithelium and endothelial cells of cavernous spaces in the corpus cavernosum and corpus spongiosum penis. Western blotting experiments demonstrated the presence of LH antigen at Mr = 97.4 and 78 kD. Quantitative RT- PCR reactions confirmed the expression of LH receptor in the penis. Our results show that <strong>LH receptor is expressed in the body of the mouse penis</strong>, thus it may directly regulate functions of penile tissue.</em></p><p>--------</p><p style="margin-left: 20px">Wikipedia (LH receptor):</p> <p style="margin-left: 20px"><em>LHCGR have been found in many types of extragonadal tissues, and the physiologic role of some has remained largely unexplored. Thus receptors have been found in the <a href="https://en.wikipedia.org/wiki/Uterus" target="_blank">uterus</a>, <a href="https://en.wikipedia.org/wiki/Sperm" target="_blank">sperm</a>, <a href="https://en.wikipedia.org/wiki/Seminal_vesicles" target="_blank">seminal vesicles</a>, <a href="https://en.wikipedia.org/wiki/Prostate" target="_blank">prostate</a>, <a href="https://en.wikipedia.org/wiki/Skin" target="_blank">skin</a>, <a href="https://en.wikipedia.org/wiki/Breast" target="_blank">breast</a>, <a href="https://en.wikipedia.org/wiki/Adrenal" target="_blank">adrenals</a>, <a href="https://en.wikipedia.org/wiki/Thyroid" target="_blank">thyroid</a>, neural <a href="https://en.wikipedia.org/wiki/Retina" target="_blank">retina</a>, <a href="https://en.wikipedia.org/wiki/Neuroendocrine" target="_blank">neuroendocrine</a> cells, and (rat) <a href="https://en.wikipedia.org/wiki/Brain" target="_blank">brain</a>.<a href="https://en.wikipedia.org/wiki/LH_receptor#cite_note-LHCGR-6" target="_blank">[6]</a></em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 178644, member: 38109"] Some references below hinting at possible wider effects of LH. It's also not just the gonadotropins that are suppressed by TRT. Further upstream you have GnRH and kisspeptin, both of which may have additional functions. [INDENT][B][I]Lei ZM, Rao CV, Kornyei JL, Licht P, Hiatt ES. Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. Endocrinology 1993;132(5):2262-70. [/I][/B][I][URL='http://endo.endojournals.org/content/132/5/2262.abstract'][B]Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain.[/B][/URL][/I][/INDENT] [INDENT][/INDENT] [INDENT][I]LH from anterior pituitary and hCG from placenta bind to a common receptor in gonadal and nongonadal reproductive tissues. There have been numerous examples suggesting that the brain may also contain hCG/LH receptors, yet there has been no evidence for their existence so far. We now demonstrate by reverse transcription-nested polymerase chain reaction and northern blotting that [B]the rat brain contains hCG/LH receptor mRNA[/B]. ...[/I][/INDENT] [INDENT][/INDENT] ----------- [INDENT][/INDENT] [INDENT][B][I]Yang E-J, Nasipak BT, Kelley DB. Direct action of gonadotropin in brain integrates behavioral and reproductive functions. Proceedings of the National Academy of Sciences 2007;104(7):2477-82. [/I][/B][I][URL='http://www.pnas.org/content/104/7/2477.full.pdf+html'][B]Direct action of gonadotropin in brain integrates behavioral and reproductive functions[/B][/URL][/I][/INDENT] [INDENT][/INDENT] [INDENT][I]Essential roles for gonadotropins in gonadal development and reproduction are well established. Over the past decade, however, the expression of luteinizing hormone receptor (LHR) has also been reported in the brain of various mammals and birds. Although suggestive, it has not yet been determined whether this expression pattern supports a novel function for gonadotropins. Here, [B]we demonstrate a CNS-mediated role of gonadotropins in a reproductive behavior[/B]: the courtship songs of the South African clawed frog, Xenopus laevis. Male advertisement calling in this species depends on a nongonadal action of gonadotropin. ...[/I][/INDENT] ----------- [INDENT][B][I]Kokk K, Kuuslahti M, Keisala T, et al. Expression of LH Receptors in the Mouse Penis. J Androl:jandrol.109.008623. [/I][/B][I][URL='http://www.andrologyjournal.org/cgi/content/abstract/jandrol.109.008623v1'][B]Expression of LH Receptors in the Mouse Penis -- Kokk et al., 10.2164/jandrol.109.008623 -- Journal of Andrology[/B][/URL] [/I][/INDENT] [INDENT][/INDENT] [INDENT][I]The role of luteinizing hormone (LH) in the regulation of normal reproductive functions in males and females is quite well established. Besides the expression of LH receptors in the target cells in gonads, it has been found in several extragonadal organs. There is no information about the expression of LH receptors in the penis up to now. The aim of present study is to investigate the expression of LH receptor in the mouse penis to see if LH effects are possible in the penis. BALB/c mice were used as donors of normal penis and testis tissue. Immunocytochemistry, Western blotting and quantitative RT-PCR reactions were used for the detection of the LH receptor. Positive immunoreaction for LH receptors was present in the nuclei of urethral epithelium and endothelial cells of cavernous spaces in the corpus cavernosum and corpus spongiosum penis. Western blotting experiments demonstrated the presence of LH antigen at Mr = 97.4 and 78 kD. Quantitative RT- PCR reactions confirmed the expression of LH receptor in the penis. Our results show that [B]LH receptor is expressed in the body of the mouse penis[/B], thus it may directly regulate functions of penile tissue.[/I][/INDENT] -------- [INDENT]Wikipedia (LH receptor):[/INDENT] [INDENT][I]LHCGR have been found in many types of extragonadal tissues, and the physiologic role of some has remained largely unexplored. Thus receptors have been found in the [URL='https://en.wikipedia.org/wiki/Uterus']uterus[/URL], [URL='https://en.wikipedia.org/wiki/Sperm']sperm[/URL], [URL='https://en.wikipedia.org/wiki/Seminal_vesicles']seminal vesicles[/URL], [URL='https://en.wikipedia.org/wiki/Prostate']prostate[/URL], [URL='https://en.wikipedia.org/wiki/Skin']skin[/URL], [URL='https://en.wikipedia.org/wiki/Breast']breast[/URL], [URL='https://en.wikipedia.org/wiki/Adrenal']adrenals[/URL], [URL='https://en.wikipedia.org/wiki/Thyroid']thyroid[/URL], neural [URL='https://en.wikipedia.org/wiki/Retina']retina[/URL], [URL='https://en.wikipedia.org/wiki/Neuroendocrine']neuroendocrine[/URL] cells, and (rat) [URL='https://en.wikipedia.org/wiki/Brain']brain[/URL].[URL='https://en.wikipedia.org/wiki/LH_receptor#cite_note-LHCGR-6'][6][/URL][/I][/INDENT] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Are there any problems with having zero gonadotrophin?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top