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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Are guys that do well on low dose clomid unicorns...or do they really exist?
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 33262" data-attributes="member: 12687"><p>You should ABSOLUTELY monitor LH levels when on a Clomid regimen, as without LH levels one cannot ascertain the degree of primary vs secondary hypogonadism by correlating the LH response with the resultant testosterone response. One should generally aim for mid to upper-normal LH levels typically 6-10mIU/mL. It is fine if there is a robust response and LH levels shoot above this range initially, but appropriate adjustments should be made thereafter to attain LH levels in this approximate range if continuing Clomid therapy for a significant duration (>30 days). </p><p></p><p>To your second question, it isn't really a matter of increasing number of leydig cells per se, but more so increasing the ACTIVITY of the leydig cells. Without adequate stimulation, the leydig cells atrophy (can down-regulate receptors as well) and significantly decrease their hormone production. Anyone with a significant decrease in the NUMBER of leydig cells likely has a strong PRIMARY hypogonadism and wouldn't benefit much from Clomid therapy in the first place. Whereas someone with a SECONDARY hypogonadism, where the leydig cells weren't being stimulated enough and may have atrophied/down-regulated receptors, thus decreasing testosterone production, may benefit from Clomid through increasing LH stimulation of the leydig cells and regaining ACTIVITY (not necessarily number) of the leydigs.</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 33262, member: 12687"] You should ABSOLUTELY monitor LH levels when on a Clomid regimen, as without LH levels one cannot ascertain the degree of primary vs secondary hypogonadism by correlating the LH response with the resultant testosterone response. One should generally aim for mid to upper-normal LH levels typically 6-10mIU/mL. It is fine if there is a robust response and LH levels shoot above this range initially, but appropriate adjustments should be made thereafter to attain LH levels in this approximate range if continuing Clomid therapy for a significant duration (>30 days). To your second question, it isn't really a matter of increasing number of leydig cells per se, but more so increasing the ACTIVITY of the leydig cells. Without adequate stimulation, the leydig cells atrophy (can down-regulate receptors as well) and significantly decrease their hormone production. Anyone with a significant decrease in the NUMBER of leydig cells likely has a strong PRIMARY hypogonadism and wouldn't benefit much from Clomid therapy in the first place. Whereas someone with a SECONDARY hypogonadism, where the leydig cells weren't being stimulated enough and may have atrophied/down-regulated receptors, thus decreasing testosterone production, may benefit from Clomid through increasing LH stimulation of the leydig cells and regaining ACTIVITY (not necessarily number) of the leydigs. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Are guys that do well on low dose clomid unicorns...or do they really exist?
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