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Dr. Saya,

I am a 45 year old man and was prescribed 90 Clomid 50 mg tablets (one per day) due to low sperm count. However, my Testosterone was normal. After 6 weeks from starting, LH was 10.6 (norm: 1.7-8.6 IU/L) and Free T=602 (196-636 pmol/L). After 9 weeks from starting, Total T=35.5 (8.4-28.8 nmol/L), FT=512, and Estradiol=143 (norm: <162 pmol/L). After 11 weeks from starting, TT=34.5F.T=482, and E2=146. At this point (11 weeks after starting), I stopped Clomid. 3 days after stopping, TT=30.8, FT=406, and E2=147. About 3 weeks after stopping, TT=26.9, and FT=261. About 6 weeks after stopping, TT=25, FT=332, and E2=46. About 14 weeks after stopping, TT=22.9, FT=266, E2=62, and DHEA-S=5.9 (norm:<9.7). Now, It is 15 weeks after stopping Clomid. My questions are:

- Is 50 mg Clomid, every day 1 pill for 3 months without AI is permitted or considered over       dose?

- TT being higher than max. normal level for about 6 weeks and without taking any AI, can       cause prostate cancer (due to high TT) or breast cancer (due to high E2)?

Will Gyno and puffy nipples caused by Clomid be disappeared after stopping clomid, by           itself?

- Do I need to take any medication such as AI (for estrogen control) or Taxoxifen (for               removing Gyno)?

Thank you very much


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