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Dr. Saya,
I am a 45 year old man and was prescribed 90 Clomid 50 mg tablets (one per day) due to low sperm count. However, my Testosterone was normal. After 6 weeks from starting, LH was 10.6 (norm: 1.7-8.6 IU/L) and Free T=602 (196-636 pmol/L). After 9 weeks from starting, Total T=35.5 (8.4-28.8 nmol/L), FT=512, and Estradiol=143 (norm: <162 pmol/L). After 11 weeks from starting, TT=34.5, F.T=482, and E2=146. At this point (11 weeks after starting), I stopped Clomid. 3 days after stopping, TT=30.8, FT=406, and E2=147. About 3 weeks after stopping, TT=26.9, and FT=261. About 6 weeks after stopping, TT=25, FT=332, and E2=46. About 14 weeks after stopping, TT=22.9, FT=266, E2=62, and DHEA-S=5.9 (norm:<9.7). Now, It is 15 weeks after stopping Clomid. My questions are:
- Is 50 mg Clomid, every day 1 pill for 3 months without AI is permitted or considered over dose?
- TT being higher than max. normal level for about 6 weeks and without taking any AI, can cause prostate cancer (due to high TT) or breast cancer (due to high E2)?
- Will Gyno and puffy nipples caused by Clomid be disappeared after stopping clomid, by itself?
- Do I need to take any medication such as AI (for estrogen control) or Taxoxifen (for removing Gyno)?
Thank you very much

<blockquote data-quote="caspian2001m" data-source="post: 119797" data-attributes="member: 20800">Dr. Saya,I am a 45 year old man and was prescribed 90 Clomid 50 mg tablets (one per day) due to low sperm count. However, my Testosterone was normal. After 6 weeks from starting, LH was 10.6 (norm: 1.7-8.6 IU/L) and Free T=602 (196-636 pmol/L). After 9 weeks from starting, Total T=35.5 (8.4-28.8 nmol/L), FT=512, and Estradiol=143 (norm: &lt;162 pmol/L). After 11 weeks from starting, TT=34.5, F.T=482, and E2=146. At this point (11 weeks after starting), I stopped Clomid. 3 days after stopping, TT=30.8, FT=406, and E2=147. About 3 weeks after stopping, TT=26.9, and FT=261. About 6 weeks after stopping, TT=25, FT=332, and E2=46. About 14 weeks after stopping, TT=22.9, FT=266, E2=62, and DHEA-S=5.9 (norm:&lt;9.7). Now, It is 15 weeks after stopping Clomid. My questions are:- Is 50 mg Clomid, every day 1 pill for 3 months without AI is permitted or considered over&nbsp; &nbsp; &nbsp;&nbsp; dose?- TT being higher than max. normal level for about 6 weeks and without taking any AI, can&nbsp; &nbsp; &nbsp;&nbsp; cause prostate cancer (due to high TT) or breast cancer (due to high E2)?- Will Gyno and puffy nipples caused by Clomid be disappeared after stopping clomid, by&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp; itself?- Do I need to take any medication such as AI (for estrogen control) or Taxoxifen (for&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp; removing Gyno)?Thank you very much</blockquote>

[QUOTE="caspian2001m, post: 119797, member: 20800"] Dr. Saya, I am a 45 year old man and was prescribed 90 Clomid 50 mg tablets (one per day) due to low sperm count. However, my Testosterone was normal. After 6 weeks from starting, LH was[B] [U]10.6[/U][/B] (norm: 1.7-8.6 IU/L) and Free T=602 (196-636 pmol/L). After 9 weeks from starting, Total T=[B][U]35.5[/U][/B] (8.4-28.8 nmol/L), FT=512, and Estradiol=143 (norm: <162 pmol/L). After 11 weeks from starting, TT=[B][U]34.5[/U], [/B]F.T=482, and E2=146. At this point (11 weeks after starting), I stopped Clomid. 3 days after stopping, TT=[B][U]30.8[/U][/B], FT=406, and E2=147. About 3 weeks after stopping, TT=26.9, and FT=261. About 6 weeks after stopping, TT=25, FT=332, and E2=46. About 14 weeks after stopping, TT=22.9, FT=266, E2=62, and DHEA-S=5.9 (norm:<9.7). Now, It is 15 weeks after stopping Clomid. My questions are: - Is 50 mg Clomid, every day 1 pill for 3 months without AI is permitted or considered over dose? - TT being higher than max. normal level for about 6 weeks and without taking any AI, can cause prostate cancer (due to high TT) or breast cancer (due to high E2)? [B]- [/B]Will Gyno and puffy nipples caused by Clomid be disappeared after stopping clomid, by itself? - Do I need to take any medication such as AI (for estrogen control) or Taxoxifen (for removing Gyno)? Thank you very much [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038