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I would say not only the higher doses but more importantly the application site as we know transdermals not only increase DHT levels better than injectable but transdermal cream applied to the scrotum will provide a much higher conversion of T----->DHT as oppose to the transdermal gels which are commonly applied to the shoulders/arms/chest/abdomen/thighs.


Higher levels of DHT derived from scrotal application of the T cream are most likely a big part of the beneficial effects (negating the effects of high e2, boosted libido).


I will not deny the fact that twice daily application can be beneficial to many but to say it is best or needed for everyone using transdermal.....highly doubtful!


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