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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Applying cream twice a day problems
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<blockquote data-quote="madman" data-source="post: 136178" data-attributes="member: 13851"><p>For him to state twice daily application offered the best symptom resolution comes across as if he is saying that it is the end all be all method when in fact men have been using the standard (once daily) transdermal application since the introduction of Androgel in 2000.</p><p></p><p></p><p>Again there are many men who have been using the standard transdermal protocol using a gel or compounded cream applied once daily (am) and feel great.....Dr. Crisler was known for treating many patients using transdermal and he prefered it over injectables as he felt it most closely mimicked the natural endogenous 24 hr circadian rhythm of a healthy young male as testosterone levels (peak) in the early am and slowly decline in the late afternoon/evening (trough).</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><a href="https://www.defymedical.com/resources/health-articles/319-my-current-best-thoughts-on-how-to-administer-trt-for-men" target="_blank">https://www.defymedical.com/resources/health-articles/319-my-current-best-thoughts-on-</a></p><p><a href="https://www.defymedical.com/resources/health-articles/319-my-current-best-thoughts-on-how-to-administer-trt-for-men" target="_blank">how-to-administer-trt-for-men</a></p><p></p><p></p><p></p><p>Dr.Crisler clearly states that:</p><p></p><p></p><p><strong><strong>TESTOSTERONE GELS AND CREAMS</strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong><span style="color: rgb(184, 49, 47)">The only way to go, in my professional opinion, if physician and patient agree on a transdermal (TD) delivery system.</span> Or TRT at all. As I have gained knowledge and experience, <span style="color: rgb(184, 49, 47)">my position is now that TD’s are vastly superior to other modalities in TRT medicine. They are easy to apply, usually well absorbed, and rapidly establish stable serum androgen levels (by the end of the third day). I recommend all practitioners first try a testosterone gel for their TRT patients. </span>Gels are better than creams, as I want the rapid T uptake into the dermal layer, which serves as reservoir for distribution throughout the day. Men do better on lower serum T levels on TD’s than IM.</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong><span style="color: rgb(184, 49, 47)">The constant variability of serum androgens provided by T gels mimic the hormones of a young man;</span> the stable daily level provided by T injections mimic the hormones of an old man; those of implantable pellets mimic the hormones of no one. <span style="color: rgb(184, 49, 47)">Entropic hormone levels are part and parcel of the process of youth. </span>Much is made of the risk posed by accidental transferal of testosterone to others, such as children or sexual partners. Simply covering with a T-shirt has been shown to block transfer of the hormone. The testosterone sinks into the skin within an hour. One may shower, or even swim, without worry, usually after four hours. I remind my patients most of us have neither the time, nor the opportunity, for romance until evening (given the usual early morning application), and a quick shower is always nice for a gentleman to “freshen up” prior to same.</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong><span style="color: rgb(184, 49, 47)">Gels and creams, like all transdermal delivery systems, provide a greater boost in DHT levels, compared to injectable testosterone preparations. </span>As DHT is responsible for all the things of manhood--literally, AllThingsMale--<span style="color: rgb(184, 49, 47)">the transdermals are better at treating sexual dysfunction than are injectables. </span>However, issues of hair loss (which I treat with a compounded topical DHT blocking mixture) and possible prostate morbidity (a contentiously debatable point, to be sure, but resolved in the negative to my mind) then come into play. This might be a good time to mention I vehemently oppose adding finasteride or similar medication</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>To end the debate on this topic, transdermal T gels/creams are more likely to elevate estrogen than injections, as long as the shots are properly administered once per week. That is because aromatase lives in the skin, along with higher concentrations of 5-AR, which converts T to E. Even so, the benefits of TD TRT outweigh the weekly convenience of shots.</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Some have reported an increase in hair growth over the application area(s). All physicians who administer TRT must be prepared to disappoint their patients at this time by pointing out, sadly, this same effect cannot be achieved upon the scalp.</strong></p></blockquote><p></p>
[QUOTE="madman, post: 136178, member: 13851"] For him to state twice daily application offered the best symptom resolution comes across as if he is saying that it is the end all be all method when in fact men have been using the standard (once daily) transdermal application since the introduction of Androgel in 2000. Again there are many men who have been using the standard transdermal protocol using a gel or compounded cream applied once daily (am) and feel great.....Dr. Crisler was known for treating many patients using transdermal and he prefered it over injectables as he felt it most closely mimicked the natural endogenous 24 hr circadian rhythm of a healthy young male as testosterone levels (peak) in the early am and slowly decline in the late afternoon/evening (trough). [URL='https://www.defymedical.com/resources/health-articles/319-my-current-best-thoughts-on-how-to-administer-trt-for-men']https://www.defymedical.com/resources/health-articles/319-my-current-best-thoughts-on-[/URL] [URL='https://www.defymedical.com/resources/health-articles/319-my-current-best-thoughts-on-how-to-administer-trt-for-men']how-to-administer-trt-for-men[/URL] Dr.Crisler clearly states that: [B][B]TESTOSTERONE GELS AND CREAMS[/B] [COLOR=rgb(184, 49, 47)]The only way to go, in my professional opinion, if physician and patient agree on a transdermal (TD) delivery system.[/COLOR] Or TRT at all. As I have gained knowledge and experience, [COLOR=rgb(184, 49, 47)]my position is now that TD’s are vastly superior to other modalities in TRT medicine. They are easy to apply, usually well absorbed, and rapidly establish stable serum androgen levels (by the end of the third day). I recommend all practitioners first try a testosterone gel for their TRT patients. [/COLOR]Gels are better than creams, as I want the rapid T uptake into the dermal layer, which serves as reservoir for distribution throughout the day. Men do better on lower serum T levels on TD’s than IM. [COLOR=rgb(184, 49, 47)]The constant variability of serum androgens provided by T gels mimic the hormones of a young man;[/COLOR] the stable daily level provided by T injections mimic the hormones of an old man; those of implantable pellets mimic the hormones of no one. [COLOR=rgb(184, 49, 47)]Entropic hormone levels are part and parcel of the process of youth. [/COLOR]Much is made of the risk posed by accidental transferal of testosterone to others, such as children or sexual partners. Simply covering with a T-shirt has been shown to block transfer of the hormone. The testosterone sinks into the skin within an hour. One may shower, or even swim, without worry, usually after four hours. I remind my patients most of us have neither the time, nor the opportunity, for romance until evening (given the usual early morning application), and a quick shower is always nice for a gentleman to “freshen up” prior to same. [COLOR=rgb(184, 49, 47)]Gels and creams, like all transdermal delivery systems, provide a greater boost in DHT levels, compared to injectable testosterone preparations. [/COLOR]As DHT is responsible for all the things of manhood--literally, AllThingsMale--[COLOR=rgb(184, 49, 47)]the transdermals are better at treating sexual dysfunction than are injectables. [/COLOR]However, issues of hair loss (which I treat with a compounded topical DHT blocking mixture) and possible prostate morbidity (a contentiously debatable point, to be sure, but resolved in the negative to my mind) then come into play. This might be a good time to mention I vehemently oppose adding finasteride or similar medication To end the debate on this topic, transdermal T gels/creams are more likely to elevate estrogen than injections, as long as the shots are properly administered once per week. That is because aromatase lives in the skin, along with higher concentrations of 5-AR, which converts T to E. Even so, the benefits of TD TRT outweigh the weekly convenience of shots. Some have reported an increase in hair growth over the application area(s). All physicians who administer TRT must be prepared to disappoint their patients at this time by pointing out, sadly, this same effect cannot be achieved upon the scalp.[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Applying cream twice a day problems
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