ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Anyone tried testosterone base (no ester)?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 184523" data-attributes="member: 13851"><p>Go nuts than.</p><p></p><p>Look up half-life of unesterified testosterone and get back to me on that one.</p><p></p><p>Regarding unesterified solvent/oil-based T highly doubtful the carrier oil would prolong the absorption rate to any significant degree let alone the volume of oil you will be injecting is minuscule.</p><p></p><p>100mg/ml strength T which would be 10 units/.10ml (10mg T) daily.</p><p></p><p>Your T levels will spike quickly and fall off fast.</p><p></p><p>Pre-workout sure!</p><p></p><p>Would be a piss poor protocol to treat low-t symptoms let alone long-term.</p><p></p><p></p><p></p><p></p><p><strong>*</strong> <strong>Schematic overview of the pharmacology of testosterone esters</strong>. <span style="color: rgb(184, 49, 47)"><em><strong>Testosterone is esterified through the 17 β hydroxyl group with fatty acid esters of different aliphatic or other chain lengths which is a biologically inactive pro-drug.</strong></em></span> <strong><span style="color: rgb(44, 130, 201)"><em>The esterified testosterone in an oil vehicle is injected deeply into a muscle forming a local drug depot from which <u>the testosterone ester is released at a slow rate determined by its Physico-chemical partitioning according to the testosterone ester’s hydrophobicity</u>. Once the testosterone ester exits the depot and enters the extracellular fluids, it is rapidly hydrolyzed by ubiquitous non-specific esterases thereby releasing the testosterone into the general circulation. </em></span></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong><em>Injectable</em></strong></p><p></p><p>The most widely used testosterone formulation for many decades has been the <em><span style="color: rgb(184, 49, 47)"><strong>intramuscular injection of <u>testosterone esters, formed by 17b-esterification of testosterone with fatty acids of various aliphatic and/or aromatic chain lengths, injected in a vegetable oil vehicle</u>. </strong></span><strong><span style="color: rgb(184, 49, 47)">This depot product relies on retarded release of the testosterone ester from the oil vehicle injection depot because esters undergo rapid hydrolysis by ubiquitous esterases to liberate free testosterone into the circulation. </span><span style="color: rgb(44, 130, 201)">The pharmacokinetics and pharmacodynamics of androgen esters are therefore primarily determined by <u>ester side-chain length, the volume of oil vehicle, and site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid</u>.</span></strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 184523, member: 13851"] Go nuts than. Look up half-life of unesterified testosterone and get back to me on that one. Regarding unesterified solvent/oil-based T highly doubtful the carrier oil would prolong the absorption rate to any significant degree let alone the volume of oil you will be injecting is minuscule. 100mg/ml strength T which would be 10 units/.10ml (10mg T) daily. Your T levels will spike quickly and fall off fast. Pre-workout sure! Would be a piss poor protocol to treat low-t symptoms let alone long-term. [B]*[/B] [B]Schematic overview of the pharmacology of testosterone esters[/B]. [COLOR=rgb(184, 49, 47)][I][B]Testosterone is esterified through the 17 β hydroxyl group with fatty acid esters of different aliphatic or other chain lengths which is a biologically inactive pro-drug.[/B][/I][/COLOR] [B][COLOR=rgb(44, 130, 201)][I]The esterified testosterone in an oil vehicle is injected deeply into a muscle forming a local drug depot from which [U]the testosterone ester is released at a slow rate determined by its Physico-chemical partitioning according to the testosterone ester’s hydrophobicity[/U]. Once the testosterone ester exits the depot and enters the extracellular fluids, it is rapidly hydrolyzed by ubiquitous non-specific esterases thereby releasing the testosterone into the general circulation. [/I][/COLOR] [I]Injectable[/I][/B] The most widely used testosterone formulation for many decades has been the [I][COLOR=rgb(184, 49, 47)][B]intramuscular injection of [U]testosterone esters, formed by 17b-esterification of testosterone with fatty acids of various aliphatic and/or aromatic chain lengths, injected in a vegetable oil vehicle[/U]. [/B][/COLOR][B][COLOR=rgb(184, 49, 47)]This depot product relies on retarded release of the testosterone ester from the oil vehicle injection depot because esters undergo rapid hydrolysis by ubiquitous esterases to liberate free testosterone into the circulation. [/COLOR][COLOR=rgb(44, 130, 201)]The pharmacokinetics and pharmacodynamics of androgen esters are therefore primarily determined by [U]ester side-chain length, the volume of oil vehicle, and site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid[/U].[/COLOR][/B][/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Anyone tried testosterone base (no ester)?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top