Reply to thread

PCSK9 inibitors are the best option for reducing lipids.  Highly effective and pretty much side effect free.  It has not been my experience that they cause hyperglycemia and a I'm not aware of any evidence that they do.  Since PCSK9 inhibitors were developed to mimic a genetic mutation that results in low levels of PCSK9, we know from studies of those with the mutation that there does not appear to be any long term adverse affect from lifelong reduced PCSK9.  Too low of LDL is unlikely and generally would require multiple lipid reducing agents before that becomes a concern.  Infants have LDL levels of ~20 mg/dl, so it takes really low levels of LDL before you're likely to have any adverse effects.