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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Anyone combine injections and cream? How do you feel?
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<blockquote data-quote="eyeheartny" data-source="post: 199443" data-attributes="member: 18882"><p>It took a fair bit of research to determine this, but there's a strong correlation between testosterone and inhibition of ACTH, which is what causes your body to release cortisol. It's very very possible that your body is especially sensitive to testosterone's effects on the HPA axis and that you get too much inhibition of ACTH. I also looked at your post history and discovered that you had been using Oxandrolone. If you are still using that, I'd also look at that as a potential culprit for your fatigue. Oxandrolone can lower SHBG levels DRAMATICALLY, which causes your free testosterone to be higher, which can be interfering with your HPA axis and inhibiting cortisol release. </p><p></p><p>I also noticed that you indicated you'd needed to use AIs in the past. There is a school of thought with TRT that if you respond positively to AIs, you should lower your dose until you get to a point where you don't need to use an AI to manage those symptoms. Your body's testosterone set point may be well be lower than what you are dosing yourself at. The combination of "needing" to use an AI plus the HPA inhibition from testosterone says to me that you may just be using too much testosterone. Certainly worth discussing with your doctor, but in my experience Defy went way off the rails and tends to overprescribe and overdose.</p></blockquote><p></p>
[QUOTE="eyeheartny, post: 199443, member: 18882"] It took a fair bit of research to determine this, but there's a strong correlation between testosterone and inhibition of ACTH, which is what causes your body to release cortisol. It's very very possible that your body is especially sensitive to testosterone's effects on the HPA axis and that you get too much inhibition of ACTH. I also looked at your post history and discovered that you had been using Oxandrolone. If you are still using that, I'd also look at that as a potential culprit for your fatigue. Oxandrolone can lower SHBG levels DRAMATICALLY, which causes your free testosterone to be higher, which can be interfering with your HPA axis and inhibiting cortisol release. I also noticed that you indicated you'd needed to use AIs in the past. There is a school of thought with TRT that if you respond positively to AIs, you should lower your dose until you get to a point where you don't need to use an AI to manage those symptoms. Your body's testosterone set point may be well be lower than what you are dosing yourself at. The combination of "needing" to use an AI plus the HPA inhibition from testosterone says to me that you may just be using too much testosterone. Certainly worth discussing with your doctor, but in my experience Defy went way off the rails and tends to overprescribe and overdose. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Anyone combine injections and cream? How do you feel?
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