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I would say that one of the primary drivers of why I decided to dose my testosterone in the physiological known range of testosterone (3-10 mg daily) was to limit the possible suppression or interference of other hormones that I know that I need to feel well. A primary one being cortisol.

Also the daily peak trough plays into this as well. Having the lower amount of testosterone during half the day is important for many things such as managing estradiol and allowing for other metabolic functions to happen. Chronically high levels can be suppressive of other functions.

Proper cortisol function is necessary for thyroid hormone to even be cellularly viable. I’m sitting here experimenting injecting 5.5mg of test enanthate daily and feeling the need to rub one out every few hours when on six times that amount I felt nothing and had terrible erectile quality.  How can that be?