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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Any new discoveries on Low SHBG curse ?
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<blockquote data-quote="awesker" data-source="post: 271777" data-attributes="member: 46293"><p>You can try taking a high quality DIM supplement. See here: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571834/" target="_blank">A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen</a></p><p></p><p>The takeaway: <strong><em>Serum SHBG also increased with DIM as compared to placebo (+ 25±22 and +1.1 ±19 nmol/L, respectively</em></strong></p><p></p><p>Although we're not breast cancer patients taking tamoxifen, taking 150 mg DIM/day definitely increases my SHBG by 5-10.</p><p></p><p>My theory is that DIM can also acts as a weak AI - there's some stuff out there that says otherwise, but, if DIM raises SHBG, you would expect total E2 levels to <em>increase </em>absent any other effects. Thus if SHBG is raised, and total E2 levels stay the same, or even increase to a lesser extent than expected by the raise in SHBG - DIM can be lowering free E2 levels.</p></blockquote><p></p>
[QUOTE="awesker, post: 271777, member: 46293"] You can try taking a high quality DIM supplement. See here: [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571834/"]A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen[/URL] The takeaway: [B][I]Serum SHBG also increased with DIM as compared to placebo (+ 25±22 and +1.1 ±19 nmol/L, respectively[/I][/B] Although we're not breast cancer patients taking tamoxifen, taking 150 mg DIM/day definitely increases my SHBG by 5-10. My theory is that DIM can also acts as a weak AI - there's some stuff out there that says otherwise, but, if DIM raises SHBG, you would expect total E2 levels to [I]increase [/I]absent any other effects. Thus if SHBG is raised, and total E2 levels stay the same, or even increase to a lesser extent than expected by the raise in SHBG - DIM can be lowering free E2 levels. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Any new discoveries on Low SHBG curse ?
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