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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Any new discoveries on Low SHBG curse ?
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<blockquote data-quote="Cataceous" data-source="post: 271335" data-attributes="member: 38109"><p>Please be more specific about your claim. Are you saying that free testosterone drops faster in the low SHBG twin? Definitely false. The free testosterone profiles are basically the same. The reasoning is outlined in <a href="https://www.excelmale.com/forum/threads/shbg-changes-after-keto.27131/post-252647" target="_blank">this post</a>. There's also a <a href="https://www.excelmale.com/forum/threads/shbg-cause-or-consequence-of-hypogonadism.25770/post-229717" target="_blank">sponge analogy for SHBG</a> that may aid in visualization. The limiting factor on the overall rate of metabolism of testosterone is the rate of production/introduction; you can't metabolize testosterone that you don't have yet. Feel free to point out any flaws in the reasoning.</p><p></p><p>The myth you are defending most likely stems from the fact that if total testosterone is somehow kept constant then a reduction in SHBG does lead to an increase in free testosterone, which would in turn mean faster metabolization and excretion. But as I've pointed out before, this is not a physiological situation. In normal men the HPTA is regulating according to free testosterone, not total. And in men on TRT, free testosterone must be driven in direct proportion to the dose rate to satisfy the law of mass action. In the new paradigm one must think of total testosterone as being a function of free testosterone, SHBG and albumin.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 271335, member: 38109"] Please be more specific about your claim. Are you saying that free testosterone drops faster in the low SHBG twin? Definitely false. The free testosterone profiles are basically the same. The reasoning is outlined in [URL='https://www.excelmale.com/forum/threads/shbg-changes-after-keto.27131/post-252647']this post[/URL]. There's also a [URL='https://www.excelmale.com/forum/threads/shbg-cause-or-consequence-of-hypogonadism.25770/post-229717']sponge analogy for SHBG[/URL] that may aid in visualization. The limiting factor on the overall rate of metabolism of testosterone is the rate of production/introduction; you can't metabolize testosterone that you don't have yet. Feel free to point out any flaws in the reasoning. The myth you are defending most likely stems from the fact that if total testosterone is somehow kept constant then a reduction in SHBG does lead to an increase in free testosterone, which would in turn mean faster metabolization and excretion. But as I've pointed out before, this is not a physiological situation. In normal men the HPTA is regulating according to free testosterone, not total. And in men on TRT, free testosterone must be driven in direct proportion to the dose rate to satisfy the law of mass action. In the new paradigm one must think of total testosterone as being a function of free testosterone, SHBG and albumin. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Any new discoveries on Low SHBG curse ?
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