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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Any concerns about long term anastrozole use in men?
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<blockquote data-quote="Nelson Vergel" data-source="post: 28351" data-attributes="member: 3"><p>This is what ipi is referring to:</p><p></p><p>"<strong>You also suggest a link between high estradiol with thrombophilia. Can you explain this finding? Would anastrozole or other E2 inhibitor improve outcome if used with TRT? </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong>Dr Glueck: We have data to show that when T is aromatized in the body to estradiol (E2), the high E2 may be the agent which directly interacts with the underlying thrombophilia to produce the clots. We do not have enough data to know whether Arimidex used to lower E2 would be protective, but we know that Arimidex alone is prothrombotic in all of the thrombophilias and hence, probably not a good idea."</p><p><strong><strong></strong></strong></p><p><strong><strong><strong><a href="https://www.excelmale.com/forum/showthread.php?3201-Can-Testosterone-Induce-Blood-Clots-and-Thrombosis-Interview-with-Dr-Charles-Glueck" target="_blank">Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck</a></strong></strong></strong></p><p><strong><strong></strong></strong></p><p><strong><strong></strong></strong></p><p><strong><strong></strong></strong>I researched oncology studies and it seems that anastrozole at the high doses used in breast cancer is better than Tamoxifen but still present a slight risk, so I am not 100% sold on Glueck's comment:<strong><strong></strong></strong></p><p><strong><strong></strong></strong></p><p><strong><strong>"</strong></strong>A systematic review has shown a 2&#8211;3&#8208;fold increase in the risk of VTE using either tamoxifen or raloxifine alone, equivalent to the risk of hormone&#8208;replacement therapy in women generally.<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653906/#ref19" target="_blank">19</a> The review found a lower but still significant risk with the newer aromatase inhibitor anastrozole (2.1% in patients on anastrozole <em>v</em> 3.5% in patients on tamoxifen).<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653906/#ref20" target="_blank">20</a>"</p><p><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653906/" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653906/</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 28351, member: 3"] This is what ipi is referring to: "[B]You also suggest a link between high estradiol with thrombophilia. Can you explain this finding? Would anastrozole or other E2 inhibitor improve outcome if used with TRT? [/B]Dr Glueck: We have data to show that when T is aromatized in the body to estradiol (E2), the high E2 may be the agent which directly interacts with the underlying thrombophilia to produce the clots. We do not have enough data to know whether Arimidex used to lower E2 would be protective, but we know that Arimidex alone is prothrombotic in all of the thrombophilias and hence, probably not a good idea." [B][B] [B][URL="https://www.excelmale.com/forum/showthread.php?3201-Can-Testosterone-Induce-Blood-Clots-and-Thrombosis-Interview-with-Dr-Charles-Glueck"]Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck[/URL][/B] [/B][/B]I researched oncology studies and it seems that anastrozole at the high doses used in breast cancer is better than Tamoxifen but still present a slight risk, so I am not 100% sold on Glueck's comment:[B][B] "[/B][/B]A systematic review has shown a 2–3‐fold increase in the risk of VTE using either tamoxifen or raloxifine alone, equivalent to the risk of hormone‐replacement therapy in women generally.[URL="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653906/#ref19"]19[/URL] The review found a lower but still significant risk with the newer aromatase inhibitor anastrozole (2.1% in patients on anastrozole [I]v[/I] 3.5% in patients on tamoxifen).[URL="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653906/#ref20"]20[/URL]" [URL]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653906/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Any concerns about long term anastrozole use in men?
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