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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Any concerns about long term anastrozole use in men?
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<blockquote data-quote="Cataceous" data-source="post: 268668" data-attributes="member: 38109"><p>I have some problems with each camp. I think it's important to consider both the absolute level of estradiol and its fraction relative to the level of testosterone. I believe high or low numbers in either metric can cause issues. The most common situation for guys on TRT is that both estradiol and testosterone are elevated, while their ratio is normal. One camp says it's no problem, neglecting the lack of evidence of long-term safety. Possible side effects, such as excess emotionalism, are supposed to be ignored. Then you have the other camp, which says that you should lower estradiol to "normal" with an AI. This camp neglects the resulting skew in the estradiol/testosterone ratio. A reduction in this ratio has known negative associations, such as a higher incidence of heart disease.</p><p></p><p>The solution is pretty obvious: lower the TRT dose so that both testosterone and estradiol are physiological. Unfortunately the more-is-better mentality still dominates when it comes to testosterone. This leads guys to try everything else instead.</p><p></p><p>Is there any place for an AI? Perhaps—in cases where it's clear that there's excessive aromatization that cannot be resolved through weight loss, etc.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 268668, member: 38109"] I have some problems with each camp. I think it's important to consider both the absolute level of estradiol and its fraction relative to the level of testosterone. I believe high or low numbers in either metric can cause issues. The most common situation for guys on TRT is that both estradiol and testosterone are elevated, while their ratio is normal. One camp says it's no problem, neglecting the lack of evidence of long-term safety. Possible side effects, such as excess emotionalism, are supposed to be ignored. Then you have the other camp, which says that you should lower estradiol to "normal" with an AI. This camp neglects the resulting skew in the estradiol/testosterone ratio. A reduction in this ratio has known negative associations, such as a higher incidence of heart disease. The solution is pretty obvious: lower the TRT dose so that both testosterone and estradiol are physiological. Unfortunately the more-is-better mentality still dominates when it comes to testosterone. This leads guys to try everything else instead. Is there any place for an AI? Perhaps—in cases where it's clear that there's excessive aromatization that cannot be resolved through weight loss, etc. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Any concerns about long term anastrozole use in men?
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