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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Anxiety and Depression increased since starting TRT
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<blockquote data-quote="Cataceous" data-source="post: 192103" data-attributes="member: 38109"><p>I haven't seen anything with enough data to be considered completely definitive. <a href="https://link.springer.com/chapter/10.1007/978-3-642-72185-4_11" target="_blank">Older work</a> by Behr and Nieschlag seems to be pretty well done. There is more recent work also supporting the ~5-day half-life, though I don't have it at my fingertips. There are also quite a few instances where anecdotal data from the forums agrees. These are cases in which a guy reports two testosterone measurements from the same injection cycle that are clearly post-peak.</p><p></p><p>I have to hedge my statements about these testosterone esters with the term "conventional formulations" because the <a href="https://www.sciencedirect.com/science/article/pii/S2050116116300058" target="_blank">clinical trial</a> for XYOSTED comes up with a much longer half-life, ostensibly because this testosterone enanthate product does not contain benzyl alcohol.</p><p></p><p>SHBG has little or no effect on the apparent half-life of a testosterone ester. The half-life is governed by the rate of absorption of the injected depot, which depends on things such as the particular ester, the depot size, the surrounding tissue, activity level, and of course the "inactive" components of the injection, including carrier oil and preservatives such as benzyl alcohol.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 192103, member: 38109"] I haven't seen anything with enough data to be considered completely definitive. [URL='https://link.springer.com/chapter/10.1007/978-3-642-72185-4_11']Older work[/URL] by Behr and Nieschlag seems to be pretty well done. There is more recent work also supporting the ~5-day half-life, though I don't have it at my fingertips. There are also quite a few instances where anecdotal data from the forums agrees. These are cases in which a guy reports two testosterone measurements from the same injection cycle that are clearly post-peak. I have to hedge my statements about these testosterone esters with the term "conventional formulations" because the [URL='https://www.sciencedirect.com/science/article/pii/S2050116116300058']clinical trial[/URL] for XYOSTED comes up with a much longer half-life, ostensibly because this testosterone enanthate product does not contain benzyl alcohol. SHBG has little or no effect on the apparent half-life of a testosterone ester. The half-life is governed by the rate of absorption of the injected depot, which depends on things such as the particular ester, the depot size, the surrounding tissue, activity level, and of course the "inactive" components of the injection, including carrier oil and preservatives such as benzyl alcohol. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Anxiety and Depression increased since starting TRT
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