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General Health & Fitness
Health Span Extension Research
Anti-Aging & weight-loss effects of Rapamycin
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<blockquote data-quote="SoCal Guy" data-source="post: 77511" data-attributes="member: 14529"><p><strong>Rapamycin alleviates inflammation and muscle weakness...in a rat model of myasthenia gravis</strong></p><p></p><p><strong><a href="http://www.bioscirep.org/content/ppbioscirep/early/2017/06/27/BSR20170767.full.pdf" target="_blank"><u>Rapamycin alleviates inflammation and muscle weakness...in a rat model of myasthenia gravis</u></a></strong></p><p><strong></strong></p><p><strong>CONCLUSIONS </strong>This study confirmed that a Treg/Th17 cell imbalance might be a cause of EAMG.</p><p></p><p>Furthermore, for the first time, we used an mTOR inhibitor, RAPA, to treat AChR antibody-positive EAMG rats. We observed symptom improvement in the EAMG animals after treatment, suggesting that the treatment was effective, which might be due to RAPA's ability to reverse the Treg/Th17 cell imbalance in EAMG. </p><p></p><p>Compared with those treated with CTX, RAPA-treated animals showed a low mortality rate and Lennon scores, but had improved body weights, indicating that RAPA is superior to CTX in treating EAMG to some extent.</p></blockquote><p></p>
[QUOTE="SoCal Guy, post: 77511, member: 14529"] [b]Rapamycin alleviates inflammation and muscle weakness...in a rat model of myasthenia gravis[/b] [B][URL="http://www.bioscirep.org/content/ppbioscirep/early/2017/06/27/BSR20170767.full.pdf"][U]Rapamycin alleviates inflammation and muscle weakness...in a rat model of myasthenia gravis[/U][/URL] CONCLUSIONS [/B]This study confirmed that a Treg/Th17 cell imbalance might be a cause of EAMG. Furthermore, for the first time, we used an mTOR inhibitor, RAPA, to treat AChR antibody-positive EAMG rats. We observed symptom improvement in the EAMG animals after treatment, suggesting that the treatment was effective, which might be due to RAPA's ability to reverse the Treg/Th17 cell imbalance in EAMG. Compared with those treated with CTX, RAPA-treated animals showed a low mortality rate and Lennon scores, but had improved body weights, indicating that RAPA is superior to CTX in treating EAMG to some extent. [/QUOTE]
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General Health & Fitness
Health Span Extension Research
Anti-Aging & weight-loss effects of Rapamycin
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