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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Androgens play a major role during male pubertal development
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<blockquote data-quote="madman" data-source="post: 193100" data-attributes="member: 13851"><p><strong>Figure 4. The molecular mechanism explaining the androgen-induced downregulation of antiMüllerian hormone (AMH) expression in pubertal Sertoli cells. (A) Before puberty, in the absence of androgen action, AMH is highly expressed in response to transcription factors SF1, GATA4 and WT1. (B) During puberty and adulthood, the ligand-bound androgen receptor (AR) inhibits AMH transcription through either a direct interaction with SF1 sites on the AMH promoter (blockage by competition, which impedes SF1 binding to its specific response elements) or a protein-protein interaction with SF1 (blockage by interaction, resulting in the inactivation of SF1 transcriptional activity). In both cases, the AR prevents SF1 from upregulating AMH expression. Reproduced from: Edelsztein NY, Rey RA. Importance of the androgen receptor signaling in gene transactivation and transrepression for pubertal maturation of the testis. Cells. 2019;8:1-17, with permission from the authors © 2019, licensee MDPI, Basel, Switzerland (open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license).</strong></p><p>[ATTACH=full]12284[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 193100, member: 13851"] [B]Figure 4. The molecular mechanism explaining the androgen-induced downregulation of antiMüllerian hormone (AMH) expression in pubertal Sertoli cells. (A) Before puberty, in the absence of androgen action, AMH is highly expressed in response to transcription factors SF1, GATA4 and WT1. (B) During puberty and adulthood, the ligand-bound androgen receptor (AR) inhibits AMH transcription through either a direct interaction with SF1 sites on the AMH promoter (blockage by competition, which impedes SF1 binding to its specific response elements) or a protein-protein interaction with SF1 (blockage by interaction, resulting in the inactivation of SF1 transcriptional activity). In both cases, the AR prevents SF1 from upregulating AMH expression. Reproduced from: Edelsztein NY, Rey RA. Importance of the androgen receptor signaling in gene transactivation and transrepression for pubertal maturation of the testis. Cells. 2019;8:1-17, with permission from the authors © 2019, licensee MDPI, Basel, Switzerland (open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license).[/B] [ATTACH type="full"]12284[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Androgens play a major role during male pubertal development
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