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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Androgens play a major role during male pubertal development
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<blockquote data-quote="madman" data-source="post: 193098" data-attributes="member: 13851"><p><strong>Figure 2. Pathways of androgen signaling. Androgens, such as testosterone (T) or dihydrotestosterone (DHT) represented as blue circles, cross the cell membrane and bind to the androgen receptor (AR) in target cells, displacing chaperones as the heat shock proteins (HSP), In the “classical” or “genomic” pathway, the ligand-bound AR translocates to the nucleus and forms homodimers that interact with androgen response elements (ARE) in target gene promoters or with other transcription factors (TF), finally regulating gene expression. In the “non-classical” or “non-genomic” pathway, the ligand-bound AR migrates to the inner side of the cell membrane and interact with the Steroid receptor coactivator (Src) and activates the epidermal growth factor receptor (EGFR) signaling cascade involving e.g. the mitogen-activated protein kinase (MEK), the extracellular signal-regulated kinase (ERK), and the cAMP response element-binding protein (CREB). Modified from: Edelsztein NY, Rey RA. Importance of the androgen receptor signaling in gene transactivation and transrepression for pubertal maturation of the testis. Cells. 2019;8:1-17, with permission from the authors © 2019, licensee MDPI, Basel, Switzerland (open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license)</strong></p><p>[ATTACH=full]12282[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 193098, member: 13851"] [B]Figure 2. Pathways of androgen signaling. Androgens, such as testosterone (T) or dihydrotestosterone (DHT) represented as blue circles, cross the cell membrane and bind to the androgen receptor (AR) in target cells, displacing chaperones as the heat shock proteins (HSP), In the “classical” or “genomic” pathway, the ligand-bound AR translocates to the nucleus and forms homodimers that interact with androgen response elements (ARE) in target gene promoters or with other transcription factors (TF), finally regulating gene expression. In the “non-classical” or “non-genomic” pathway, the ligand-bound AR migrates to the inner side of the cell membrane and interact with the Steroid receptor coactivator (Src) and activates the epidermal growth factor receptor (EGFR) signaling cascade involving e.g. the mitogen-activated protein kinase (MEK), the extracellular signal-regulated kinase (ERK), and the cAMP response element-binding protein (CREB). Modified from: Edelsztein NY, Rey RA. Importance of the androgen receptor signaling in gene transactivation and transrepression for pubertal maturation of the testis. Cells. 2019;8:1-17, with permission from the authors © 2019, licensee MDPI, Basel, Switzerland (open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license)[/B] [ATTACH type="full"]12282[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Androgens play a major role during male pubertal development
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