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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Androgen Receptor binding, T/DHT/Pregnenolone/Progesterone
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 34096" data-attributes="member: 12687"><p>Good stuff and good thoughts, Vince. I'll try to hit on all of them here for everyone's benefit and we can certainly discuss in more detail when you and I chat directly. </p><p></p><p>First, ERO is absolutely correct...progesterone can act as an inhibitor of 5-AR, but it is a WEAK inhibitor unless at high levels. Similar to the progestin like effect of 19-nor testosterone derivatives (nandrolone)...we all know the negative impact that nandrolone can have on libido, erections, etc (deca d**k), but that is dose dependent and typically worse/more pronounced at higher dosages. </p><p></p><p>I haven't personally seen any data of pregnenolone binding to androgen receptors with a stronger affinity than T/DHT. In fact, I am only aware of pregnenolone binding with MUTATED androgen receptors in some forms of prostate cancer (again, mutated androgen receptors, not the native receptors). </p><p></p><p>Progesterone is interesting, but typically binds to the progesterone receptor. The progesterone receptor IS the closest structurally to the androgen receptor and I have heard of androgen receptor binding, but again have not seen anything convincing that shows it binding with a stronger affinity than the androgens themselves (as we would expect). Further, the concentrations of progesterone are so much less in the male body than the concentrations of androgens that the "mass effect" of the androgens is overwhelming. I don't believe progesterone (at physiologic MALE levels) has much of a chance to be of clinical significance in interacting with the androgen receptors given its inherent disadvantages in the male body (and its affinity for its own receptor).</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 34096, member: 12687"] Good stuff and good thoughts, Vince. I'll try to hit on all of them here for everyone's benefit and we can certainly discuss in more detail when you and I chat directly. First, ERO is absolutely correct...progesterone can act as an inhibitor of 5-AR, but it is a WEAK inhibitor unless at high levels. Similar to the progestin like effect of 19-nor testosterone derivatives (nandrolone)...we all know the negative impact that nandrolone can have on libido, erections, etc (deca d**k), but that is dose dependent and typically worse/more pronounced at higher dosages. I haven't personally seen any data of pregnenolone binding to androgen receptors with a stronger affinity than T/DHT. In fact, I am only aware of pregnenolone binding with MUTATED androgen receptors in some forms of prostate cancer (again, mutated androgen receptors, not the native receptors). Progesterone is interesting, but typically binds to the progesterone receptor. The progesterone receptor IS the closest structurally to the androgen receptor and I have heard of androgen receptor binding, but again have not seen anything convincing that shows it binding with a stronger affinity than the androgens themselves (as we would expect). Further, the concentrations of progesterone are so much less in the male body than the concentrations of androgens that the "mass effect" of the androgens is overwhelming. I don't believe progesterone (at physiologic MALE levels) has much of a chance to be of clinical significance in interacting with the androgen receptors given its inherent disadvantages in the male body (and its affinity for its own receptor). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Androgen Receptor binding, T/DHT/Pregnenolone/Progesterone
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