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ExcelFemale
HRT in Women
Androgen Levels in Women Across the Menstrual Cycle
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<blockquote data-quote="madman" data-source="post: 257907" data-attributes="member: 13851"><p>[URL unfurl="true"]https://www.brighamhealthonamission.org/2023/07/03/peak-total-and-free-testosterone-in-women-of-reproductive-age-are-higher-than-previously-reported/[/URL]</p><p></p><p></p><p></p><p><strong>Results</strong></p><ul> <li data-xf-list-type="ul">Androgen levels in women during the menstrual cycle:<ul> <li data-xf-list-type="ul">Total T increased from 15.6 ng/dL in early luteal phase to 43.6 ng/dL at mid-cycle (P=0.01), no significant differences between luteal and follicular phases.</li> <li data-xf-list-type="ul">Free T increased from 9.00 pg/mL in early luteal phase to 15.6 pg/mL at mid-cycle (P=0.05).</li> <li data-xf-list-type="ul">Mean DHT level showed no significant change.</li> <li data-xf-list-type="ul">Ratio of total T to DHT showed no significant change.</li> <li data-xf-list-type="ul">SHBG exhibited substantial variation but no significant change.</li> <li data-xf-list-type="ul">Absolute T levels in this study were higher than some prior studies.</li> </ul></li> </ul><p></p><ul> <li data-xf-list-type="ul">DHT-to-T Ratio in Women vs. Men:<ul> <li data-xf-list-type="ul">Women had a DHT level one-fourth of total T in all menstrual phases, while men had one-thirteenth.</li> <li data-xf-list-type="ul">Women also had significantly higher SHBG levels than men.</li> <li data-xf-list-type="ul">These results remained unchanged after adjusting for age and body mass index.</li> <li data-xf-list-type="ul">Women have significantly higher DHT levels relative to total T than men, with unknown clinical significance.</li> </ul></li> </ul><p></p><p></p><p></p><p><em>Commercial labs' T assays disregard menstrual cycle phase, lack procedural details (like equilibrium dialysis and sampling method), and participant characteristics for reference ranges. Urgent need to establish cycle-related reference ranges and re-evaluate commercial labs' values to prevent misdiagnosis of androgen disorders.</em></p></blockquote><p></p>
[QUOTE="madman, post: 257907, member: 13851"] [URL unfurl="true"]https://www.brighamhealthonamission.org/2023/07/03/peak-total-and-free-testosterone-in-women-of-reproductive-age-are-higher-than-previously-reported/[/URL] [B]Results[/B] [LIST] [*]Androgen levels in women during the menstrual cycle: [LIST] [*]Total T increased from 15.6 ng/dL in early luteal phase to 43.6 ng/dL at mid-cycle (P=0.01), no significant differences between luteal and follicular phases. [*]Free T increased from 9.00 pg/mL in early luteal phase to 15.6 pg/mL at mid-cycle (P=0.05). [*]Mean DHT level showed no significant change. [*]Ratio of total T to DHT showed no significant change. [*]SHBG exhibited substantial variation but no significant change. [*]Absolute T levels in this study were higher than some prior studies. [/LIST] [/LIST] [LIST] [*]DHT-to-T Ratio in Women vs. Men: [LIST] [*]Women had a DHT level one-fourth of total T in all menstrual phases, while men had one-thirteenth. [*]Women also had significantly higher SHBG levels than men. [*]These results remained unchanged after adjusting for age and body mass index. [*]Women have significantly higher DHT levels relative to total T than men, with unknown clinical significance. [/LIST] [/LIST] [I]Commercial labs' T assays disregard menstrual cycle phase, lack procedural details (like equilibrium dialysis and sampling method), and participant characteristics for reference ranges. Urgent need to establish cycle-related reference ranges and re-evaluate commercial labs' values to prevent misdiagnosis of androgen disorders.[/I] [/QUOTE]
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ExcelFemale
HRT in Women
Androgen Levels in Women Across the Menstrual Cycle
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