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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Androgel vs compounded cream
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<blockquote data-quote="madman" data-source="post: 180004" data-attributes="member: 13851"><p><span style="color: rgb(184, 49, 47)">I was wondering if androgel sustains levels of t longer than compounded creams.</span></p><p></p><p>No.</p><p></p><p>Absorption will be the same (9-14%) and the daily application of the T gel/cream to the skin surface will result in the thinnest layer of skin (stratum corneum) acting as a reservoir that will release the T slowly into circulation eventually leading to steady-state blood levels.</p><p></p><p>When applied daily steady state is achieved in 48-72hrs.</p><p></p><p></p><p><span style="color: rgb(184, 49, 47)">Why Do androgel and generics use gels instead of a cream base?</span></p><p></p><p><span style="color: rgb(0, 0, 0)">Dries rapidly.</span></p><p></p><p></p><p><span style="color: rgb(184, 49, 47)">Is there some scientific Evidence out there that say gels are slower release and more effective than creams? </span></p><p></p><p>No.</p><p></p><p>Transdermal application is absorbed within the first few hours.</p><p></p><p>Effectiveness of one's protocol comes down to absorption, the dose of T used and of course</p><p>adhering to the daily application of the T gel/cream.</p><p></p><p>As already stated <span style="color: rgb(184, 49, 47)">[USER=40083]@Bryan_K77[/USER]</span> the main downfall of the big pharma gels is the concentration is very low (1-2%) compared to compounded (5-20%) therefore a larger volume of the big pharma gels would need to be applied over a larger surface area on the skin in order to improve absorption.</p><p></p><p>Also when using the lower concentration big pharma gels in most men a higher dose 10 grams gel (100mg of T) would need to be used in order to achieve high/normal T levels as 5 grams gel (50mg of T) will result in average T levels for most.</p><p></p><p>Although big pharma gels are commonly demonized do understand that many men do respond well and can achieve high T levels when using a higher dose of 10 grams gel (100mg T).</p><p></p><p>Regardless of the dose used some men are just poor absorbers and using the low concentration big pharma transdermal gels is ineffective.</p><p></p><p></p><p></p><p></p><p>The main reason big pharma uses gels as the base is:</p><p></p><p></p><p><span style="color: rgb(44, 130, 201)">[URL unfurl="true"]https://www.tandfonline.com/doi/full/10.1080/10717540701203075[/URL]</span></p><p><span style="color: rgb(184, 49, 47)">On application of a hydroalcoholic gel, such as Androgel®, to the skin,<u> rapid evaporation of alcohol causes the gel to dry immediately</u>, after which T penetrates through the skin into the systemic circulation. </span></p><p></p><p><span style="color: rgb(44, 130, 201)">[URL unfurl="true"]https://academic.oup.com/jcem/article/85/12/4500/2852336[/URL]</span></p><p><span style="color: rgb(184, 49, 47)">When T is applied to the skin surface as a hydroalcoholic gel, <u>the gel dries rapidly, and the steroid is absorbed into the stratum corneum, which serves as a reservoir</u>. <u>The reservoir in the skin releases T into the circulation slowly over several hours, resulting in steady-state serum levels of the hormones.</u></span></p><p></p><p><span style="color: rgb(44, 130, 201)">[URL unfurl="true"]https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357[/URL]</span></p><p><span style="color: rgb(184, 49, 47)">Transdermal absorption depends on <u>testosterone forming a local depot in the stratum corneum, the dead skin cell layer which limits permeability of small molecules through the skin, to allow for prolonged testosterone delivery</u>.</span></p></blockquote><p></p>
[QUOTE="madman, post: 180004, member: 13851"] [COLOR=rgb(184, 49, 47)]I was wondering if androgel sustains levels of t longer than compounded creams.[/COLOR] No. Absorption will be the same (9-14%) and the daily application of the T gel/cream to the skin surface will result in the thinnest layer of skin (stratum corneum) acting as a reservoir that will release the T slowly into circulation eventually leading to steady-state blood levels. When applied daily steady state is achieved in 48-72hrs. [COLOR=rgb(184, 49, 47)]Why Do androgel and generics use gels instead of a cream base?[/COLOR] [COLOR=rgb(0, 0, 0)]Dries rapidly.[/COLOR] [COLOR=rgb(184, 49, 47)]Is there some scientific Evidence out there that say gels are slower release and more effective than creams? [/COLOR] No. Transdermal application is absorbed within the first few hours. Effectiveness of one's protocol comes down to absorption, the dose of T used and of course adhering to the daily application of the T gel/cream. As already stated [COLOR=rgb(184, 49, 47)][USER=40083]@Bryan_K77[/USER][/COLOR] the main downfall of the big pharma gels is the concentration is very low (1-2%) compared to compounded (5-20%) therefore a larger volume of the big pharma gels would need to be applied over a larger surface area on the skin in order to improve absorption. Also when using the lower concentration big pharma gels in most men a higher dose 10 grams gel (100mg of T) would need to be used in order to achieve high/normal T levels as 5 grams gel (50mg of T) will result in average T levels for most. Although big pharma gels are commonly demonized do understand that many men do respond well and can achieve high T levels when using a higher dose of 10 grams gel (100mg T). Regardless of the dose used some men are just poor absorbers and using the low concentration big pharma transdermal gels is ineffective. The main reason big pharma uses gels as the base is: [COLOR=rgb(44, 130, 201)][URL unfurl="true"]https://www.tandfonline.com/doi/full/10.1080/10717540701203075[/URL][/COLOR] [COLOR=rgb(184, 49, 47)]On application of a hydroalcoholic gel, such as Androgel®, to the skin,[U] rapid evaporation of alcohol causes the gel to dry immediately[/U], after which T penetrates through the skin into the systemic circulation. [/COLOR] [COLOR=rgb(44, 130, 201)][URL unfurl="true"]https://academic.oup.com/jcem/article/85/12/4500/2852336[/URL][/COLOR] [COLOR=rgb(184, 49, 47)]When T is applied to the skin surface as a hydroalcoholic gel, [U]the gel dries rapidly, and the steroid is absorbed into the stratum corneum, which serves as a reservoir[/U]. [U]The reservoir in the skin releases T into the circulation slowly over several hours, resulting in steady-state serum levels of the hormones.[/U][/COLOR] [COLOR=rgb(44, 130, 201)][URL unfurl="true"]https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357[/URL][/COLOR] [COLOR=rgb(184, 49, 47)]Transdermal absorption depends on [U]testosterone forming a local depot in the stratum corneum, the dead skin cell layer which limits permeability of small molecules through the skin, to allow for prolonged testosterone delivery[/U].[/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Androgel vs compounded cream
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