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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
ANDRODERM® (TDS)
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<blockquote data-quote="madman" data-source="post: 235726" data-attributes="member: 13851"><p>Patch vs short-acting esterified T (propionate).</p><p></p><p>Different PKs.</p><p></p><p>Even then you would have a hard time mimicking the natural peak which occurs between 6-8 am!</p><p></p><p><strong><em>*nightly application of the patch results in peak levels occurring in the morning after application and decreasing slowly until system removal, mimicking the circadian patterns reported in healthy, young men</em></strong></p><p></p><p></p><p></p><p>Keep in mind these studies were done using 25 and 50 mg TP.</p><p></p><p>Notice the T levels achieved let alone how long blood levels can stay elevated when using such doses.</p><p></p><p>Far from a daily crash and burn!</p><p></p><p><strong><em>post #70</em></strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/tips-on-how-to-blend-propionate-with-enanthate-or-cypionate.23485/page-4#post-20534[/URL]</p><p></p><p></p><p></p><p></p><p>This is why men not on TRT need to have blood work done in the early AM as we want to test at the true peak.</p><p></p><p><strong><em>*During the 24hr circadian rhythm of a healthy young male testosterone levels will gradually start to rise overnight reaching a peak between 6-8 am </em></strong></p><p><strong><em></em></strong></p><p><strong><em>*declining levels in the late afternoon/early evening reaching a trough between 6-8 pm</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*Fluctuations from peak--->trough would be around 20-25%</em></strong></p><p></p><p><em><strong>*Natural endogenous testosterone secretion is pulsatile and diurnal</strong></em></p><p><em><strong></strong></em></p><p><em><strong>[ATTACH=full]26238[/ATTACH]</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong><u>Hourly serum testosterone levels in normal young (n = 17) and older (n = 12) males</u>. The circadian rhythm is lost in older males. Blood samples were obtained using an indwelling peripheral venous cannula, which allowed free movement and normal sleep.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>Data from: Bremner WJ, Vitiello MV, Prinz PN. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983; 56:1278.</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 235726, member: 13851"] Patch vs short-acting esterified T (propionate). Different PKs. Even then you would have a hard time mimicking the natural peak which occurs between 6-8 am! [B][I]*nightly application of the patch results in peak levels occurring in the morning after application and decreasing slowly until system removal, mimicking the circadian patterns reported in healthy, young men[/I][/B] Keep in mind these studies were done using 25 and 50 mg TP. Notice the T levels achieved let alone how long blood levels can stay elevated when using such doses. Far from a daily crash and burn! [B][I]post #70[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/tips-on-how-to-blend-propionate-with-enanthate-or-cypionate.23485/page-4#post-20534[/URL] This is why men not on TRT need to have blood work done in the early AM as we want to test at the true peak. [B][I]*During the 24hr circadian rhythm of a healthy young male testosterone levels will gradually start to rise overnight reaching a peak between 6-8 am *declining levels in the late afternoon/early evening reaching a trough between 6-8 pm *Fluctuations from peak--->trough would be around 20-25%[/I][/B] [I][B]*Natural endogenous testosterone secretion is pulsatile and diurnal [ATTACH type="full" alt="Screenshot (18100).png"]26238[/ATTACH] [U]Hourly serum testosterone levels in normal young (n = 17) and older (n = 12) males[/U]. The circadian rhythm is lost in older males. Blood samples were obtained using an indwelling peripheral venous cannula, which allowed free movement and normal sleep. Data from: Bremner WJ, Vitiello MV, Prinz PN. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983; 56:1278.[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
ANDRODERM® (TDS)
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