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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
ANDRODERM® (TDS)
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<blockquote data-quote="madman" data-source="post: 235641" data-attributes="member: 13851"><p>Of course, it does!</p><p></p><p>It would be considered the only method which most closely mimics the 24hr natural circadian rhythm of a healthy young male.</p><p></p><p><strong><em>*Only Androderm®, an evening PA transdermal patch, closely replicates the normal T circadian rhythmicity</em></strong></p><p></p><p>Apply the patch before bed and peak levels will be achieved in the early AM (8 hrs post-application).</p><p></p><p>One daily peak/trough 24/7!</p><p></p><p>Most would need a 5 mg/day dose to achieve robust T levels.</p><p></p><p>If you are content with achieving T levels within the physiological range and dealing with possible skin irritation then I see no reason to not give it a go.</p><p></p><p>Hope your insurance covers treatment as it is most likely expensive.</p><p></p><p></p><p></p><p></p><p><strong>My reply from a previous thread:</strong></p><p></p><p></p><p>Unfortunately most caught up on that more T is better mentality will continue to struggle as they will always be searching for something that will never be there.</p><p></p><p>Many will refuse to settle for feeling NORMAL and be chasing that so-called OPTIMAL until the cows come home.</p><p></p><p>Never-ending merry-go-round.</p><p></p><p>You have people on the forums going on and on about <strong><em>so-called optimal let alone everything being in balance</em></strong> yet these same individuals are trying their damnedest to micro-manage estradiol/DHT/prolactin/DHEA and the laundry list goes on yet <em><strong>when it comes to T are running levels well beyond what their body could ever produce endogenously let alone what level they were genetically at in their PRIME</strong></em><strong><em> (late teens/the early 20s).</em></strong></p><p></p><p>No male in his prime (late teens/early 20s) was producing absurdly high peak or trough TT/FT levels let alone 24/7 (steady-state).</p><p></p><p>Top it all off that your HPGA is shut down and <em><strong>most are not replacing physiological levels of T they are FORCING levels upon THEMSELVES WELL BEYOND what one could endogenously ever produce</strong></em><strong><em>.</em></strong></p><p></p><p>Unfortunately too many want to be jacked up on T 24/7.</p><p></p><p>When it comes to building muscle high T levels steady-state is where it's at and there is no denying such.</p><p></p><p>The sad fact of the matter is many are brainwashed into thinking that more T is better.</p><p></p><p>For many years we have been stressing the point that many are overmedicated when it comes to testosterone therapy.</p><p></p><p>Too many caught up on that neanderthal mindset you know that more T is better mentality.</p><p></p><p>Unfortunately many are jacked up on T from the get-go let alone many are also dick riding that so-called OPTIMAL bulls**t!</p><p></p><p>Too many get caught up in expecting to feel great 24/7 once on trt as if testosterone is going to cure all that ails them.</p><p></p><p>So much misinformation spewed on the numerous forums/gootube.</p><p></p><p></p><p><em><strong>*neanderthal mindset that more T is better</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*HIGH T = raging libido/titanium erections</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*HIGH T = OPTIMAL as in that fairytale everyone is chasing.....you know the one with raging libido/titanium erections 24/7, unlimited amounts of energy, stellar mood (Mr. Rogers neighborhood), packing on muscle like the h<em>ulk with the recovery abilities of wolverine</em></strong></em></p><p></p><p></p><p>Never going to change especially when everyone keeps pushing the more T is better mentality on most of the other forums and it does not help when many are loaded with are beloved (LOL) blast n cruiserZZZ!</p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/an-update-on-the-available-and-emerging-pharmacotherapy-for-adults-with-td-available-in-the-usa.23276/[/URL]</p><p></p><p><strong>3. Transdermal</strong></p><p></p><p><em>Transdermal formulations depend on testosterone reaching systemic circulation directly through the skin, bypassing potentially detrimental first-pass metabolism in the liver. All transdermal delivery methods of testosterone rely on hydroalcoholic vehicles that quickly dry after application, creating a reservoir of testosterone on the skin. Some formulations are combined with penetration enhancers which disrupt the stratum corneum layer of the skin to increase delivery into circulation [17]. Transdermal formulations of testosterone come in varying mediums and concentrations ranging from gels and patches to liquid sprays.</em></p><p><em></em></p><p><em><strong>In general, the advantages of transdermal systems are their lack of invasive application, ease of use, and ability to sustain testosterone levels without significant fluctuations [18]. Disadvantages include potential skin irritation (especially in the case of patches) and the potential for transference (unique to gels and solutions). </strong>Due to the risk of transference, especially with children, testosterone gels carry an FDA-boxed warning. For this reason, patients on gels are recommended to wash their hands after each application and apply the medication on areas that are usually covered with clothing.</em></p><p></p><p></p><p></p><p></p><p><strong>3.1. Androderm®</strong></p><p></p><p><em><strong>The first transdermal systems were developed in the form of adhesive patches. Currently, one of the only patches approved in the United States is Androderm (AbbVie, North Chicago, IL, USA) [19]. The patch consists of a microporous membrane with a peripheral mucoadhesive layer and a central reservoir with the entire system contained by an impermeable backing film. <u>The contents of the reservoir include testosterone, the only active ingredient dissolved in a hydroalcoholic gel</u>. <u>Patches are available in dosages of 2, 2.5, 4, and 5 mg of testosterone</u>. <u>The recommended starting dose is one 4 mg patch per day, one 5 mg patch per day, or two 2.5 mg patches per day, applied centrally to the back, abdomen, arms, or thighs</u>. <u>Maximum testosterone levels are reached at 8 hours after application</u>. Testosterone levels should be checked 2 weeks after starting treatment to allow for proper titration.</strong></em></p><p></p><p><em><strong>The pharmacokinetics, efficacy, and safety of Androderm have been studied in comparison to IM testosterone enanthate [20]. <u>Androderm was initiated at a starting dose of 5 mg in 33 patients and titrated up or down based on adverse events or testosterone levels</u>. <u>The average testosterone levels of the Androderm group were 517±176 ng/dL by the end of the study, with maximum levels of 765 ± 277 ng/dL reached around 8 hours after application</u>. <u>Testosterone was absorbed continuously throughout the 24-hour period and decreased after the removal of the patch with a half-life of about 70 minutes</u>. Sixty percent of patients experienced transient skin irritation in the study, however, only three patients discontinued treatment for this reason.</strong></em></p><p><em></em></p></blockquote><p></p>
[QUOTE="madman, post: 235641, member: 13851"] Of course, it does! It would be considered the only method which most closely mimics the 24hr natural circadian rhythm of a healthy young male. [B][I]*Only Androderm®, an evening PA transdermal patch, closely replicates the normal T circadian rhythmicity[/I][/B] Apply the patch before bed and peak levels will be achieved in the early AM (8 hrs post-application). One daily peak/trough 24/7! Most would need a 5 mg/day dose to achieve robust T levels. If you are content with achieving T levels within the physiological range and dealing with possible skin irritation then I see no reason to not give it a go. Hope your insurance covers treatment as it is most likely expensive. [B]My reply from a previous thread:[/B] Unfortunately most caught up on that more T is better mentality will continue to struggle as they will always be searching for something that will never be there. Many will refuse to settle for feeling NORMAL and be chasing that so-called OPTIMAL until the cows come home. Never-ending merry-go-round. You have people on the forums going on and on about [B][I]so-called optimal let alone everything being in balance[/I][/B] yet these same individuals are trying their damnedest to micro-manage estradiol/DHT/prolactin/DHEA and the laundry list goes on yet [I][B]when it comes to T are running levels well beyond what their body could ever produce endogenously let alone what level they were genetically at in their PRIME[/B][/I][B][I] (late teens/the early 20s).[/I][/B] No male in his prime (late teens/early 20s) was producing absurdly high peak or trough TT/FT levels let alone 24/7 (steady-state). Top it all off that your HPGA is shut down and [I][B]most are not replacing physiological levels of T they are FORCING levels upon THEMSELVES WELL BEYOND what one could endogenously ever produce[/B][/I][B][I].[/I][/B] Unfortunately too many want to be jacked up on T 24/7. When it comes to building muscle high T levels steady-state is where it's at and there is no denying such. The sad fact of the matter is many are brainwashed into thinking that more T is better. For many years we have been stressing the point that many are overmedicated when it comes to testosterone therapy. Too many caught up on that neanderthal mindset you know that more T is better mentality. Unfortunately many are jacked up on T from the get-go let alone many are also dick riding that so-called OPTIMAL bulls**t! Too many get caught up in expecting to feel great 24/7 once on trt as if testosterone is going to cure all that ails them. So much misinformation spewed on the numerous forums/gootube. [I][B]*neanderthal mindset that more T is better *HIGH T = raging libido/titanium erections *HIGH T = OPTIMAL as in that fairytale everyone is chasing.....you know the one with raging libido/titanium erections 24/7, unlimited amounts of energy, stellar mood (Mr. Rogers neighborhood), packing on muscle like the h[I]ulk with the recovery abilities of wolverine[/I][/B][/I] Never going to change especially when everyone keeps pushing the more T is better mentality on most of the other forums and it does not help when many are loaded with are beloved (LOL) blast n cruiserZZZ! [URL unfurl="true"]https://www.excelmale.com/forum/threads/an-update-on-the-available-and-emerging-pharmacotherapy-for-adults-with-td-available-in-the-usa.23276/[/URL] [B]3. Transdermal[/B] [I]Transdermal formulations depend on testosterone reaching systemic circulation directly through the skin, bypassing potentially detrimental first-pass metabolism in the liver. All transdermal delivery methods of testosterone rely on hydroalcoholic vehicles that quickly dry after application, creating a reservoir of testosterone on the skin. Some formulations are combined with penetration enhancers which disrupt the stratum corneum layer of the skin to increase delivery into circulation [17]. Transdermal formulations of testosterone come in varying mediums and concentrations ranging from gels and patches to liquid sprays. [B]In general, the advantages of transdermal systems are their lack of invasive application, ease of use, and ability to sustain testosterone levels without significant fluctuations [18]. Disadvantages include potential skin irritation (especially in the case of patches) and the potential for transference (unique to gels and solutions). [/B]Due to the risk of transference, especially with children, testosterone gels carry an FDA-boxed warning. For this reason, patients on gels are recommended to wash their hands after each application and apply the medication on areas that are usually covered with clothing.[/I] [B]3.1. Androderm®[/B] [I][B]The first transdermal systems were developed in the form of adhesive patches. Currently, one of the only patches approved in the United States is Androderm (AbbVie, North Chicago, IL, USA) [19]. The patch consists of a microporous membrane with a peripheral mucoadhesive layer and a central reservoir with the entire system contained by an impermeable backing film. [U]The contents of the reservoir include testosterone, the only active ingredient dissolved in a hydroalcoholic gel[/U]. [U]Patches are available in dosages of 2, 2.5, 4, and 5 mg of testosterone[/U]. [U]The recommended starting dose is one 4 mg patch per day, one 5 mg patch per day, or two 2.5 mg patches per day, applied centrally to the back, abdomen, arms, or thighs[/U]. [U]Maximum testosterone levels are reached at 8 hours after application[/U]. Testosterone levels should be checked 2 weeks after starting treatment to allow for proper titration.[/B][/I] [B][/B] [I][B]The pharmacokinetics, efficacy, and safety of Androderm have been studied in comparison to IM testosterone enanthate [20]. [U]Androderm was initiated at a starting dose of 5 mg in 33 patients and titrated up or down based on adverse events or testosterone levels[/U]. [U]The average testosterone levels of the Androderm group were 517±176 ng/dL by the end of the study, with maximum levels of 765 ± 277 ng/dL reached around 8 hours after application[/U]. [U]Testosterone was absorbed continuously throughout the 24-hour period and decreased after the removal of the patch with a half-life of about 70 minutes[/U]. Sixty percent of patients experienced transient skin irritation in the study, however, only three patients discontinued treatment for this reason.[/B] [/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
ANDRODERM® (TDS)
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