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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Anastrozole follow up question...
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<blockquote data-quote="jkozlow3" data-source="post: 120956" data-attributes="member: 20866"><p>I don't think that's how Arimidex works. Arimidex doesn't kill E2 that's already been made - it helps to block the E2 production in the first place by inhibiting the enzyme that produces E2. In my mind, you want to block the enzyme just before E2 levels start to rise. I would think that blocking the enzyme AFTER E2 rises would do little good.</p><p></p><p>Based on blood work that I've run on consecutive days, my E2 ALWAYS peaks ~24 hours after an IM injection (give or take - I've never run blood at 12 hours after an injection) and my T peaks somewhere in the 24-48 hour period. At the 48 hour mark, my E2 is already much lower than at the 24 hour mark. I imagine most (not all) people's bodies respond similarly to mine and they just don't realize it because they've never run blood work on consecutive days.</p><p></p><p>So in my case, it wouldn't make sense to take Arimidex 24 hours after an injection after the E2 has already peaked. I would think you'd want it in your system before the bulk of the E2 is produced. In my body, this happens pretty darn quickly after an injection.</p><p></p><p>This is my logic and I just started on Arimidex 0.25mg E3D with injections a week ago. I haven't run blood work yet however. My E2 levels are typically 50+ 24 hours after an injection and drop down to ~39 and stay there by the 48-72 hour mark. Hoping to get my E2 levels down to the mid/high 20s.</p><p></p><p>I think a TT:E2 ratio of around 25:1-30:1 (give or take) is a good target and is more in line with what healthy young men in their 20s and 30s have based on research I've done. 750:30 & 700:28 = 25:1 and 800:27 & 850:28 = 30:1. I know some much lower ratios get mentioned here as desirable/acceptable, but I've not seen research that leads me to believe that ratios much lower than 20:1 are anywhere near "normal". I've also not seen any studies that have shown young men with E2 averages in the 30s despite having high in range TT levels.</p><p></p><p>If anyone knows of studies showing measurements of healthy young males with TT & E2 measurements that support ratios of around 20:1 and lower, please pass them my way however!</p></blockquote><p></p>
[QUOTE="jkozlow3, post: 120956, member: 20866"] I don't think that's how Arimidex works. Arimidex doesn't kill E2 that's already been made - it helps to block the E2 production in the first place by inhibiting the enzyme that produces E2. In my mind, you want to block the enzyme just before E2 levels start to rise. I would think that blocking the enzyme AFTER E2 rises would do little good. Based on blood work that I've run on consecutive days, my E2 ALWAYS peaks ~24 hours after an IM injection (give or take - I've never run blood at 12 hours after an injection) and my T peaks somewhere in the 24-48 hour period. At the 48 hour mark, my E2 is already much lower than at the 24 hour mark. I imagine most (not all) people's bodies respond similarly to mine and they just don't realize it because they've never run blood work on consecutive days. So in my case, it wouldn't make sense to take Arimidex 24 hours after an injection after the E2 has already peaked. I would think you'd want it in your system before the bulk of the E2 is produced. In my body, this happens pretty darn quickly after an injection. This is my logic and I just started on Arimidex 0.25mg E3D with injections a week ago. I haven't run blood work yet however. My E2 levels are typically 50+ 24 hours after an injection and drop down to ~39 and stay there by the 48-72 hour mark. Hoping to get my E2 levels down to the mid/high 20s. I think a TT:E2 ratio of around 25:1-30:1 (give or take) is a good target and is more in line with what healthy young men in their 20s and 30s have based on research I've done. 750:30 & 700:28 = 25:1 and 800:27 & 850:28 = 30:1. I know some much lower ratios get mentioned here as desirable/acceptable, but I've not seen research that leads me to believe that ratios much lower than 20:1 are anywhere near "normal". I've also not seen any studies that have shown young men with E2 averages in the 30s despite having high in range TT levels. If anyone knows of studies showing measurements of healthy young males with TT & E2 measurements that support ratios of around 20:1 and lower, please pass them my way however! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Anastrozole follow up question...
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