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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Anastrazole dosage
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<blockquote data-quote="Blackhawk" data-source="post: 132248" data-attributes="member: 16042"><p>Your stated symptoms can come from many other things besides high estradiol. for example, how's your hematocrit? How about thyroid?</p><p></p><p>And how long have you waited for steady state after adjusting dosage? If you reduced dosage it is probable you will feel like crap for up to 6-8 weeks until things stabilize. I had to undergo dosage reduction from 150 to 84mg/week spread out over 6 months to try to bring down hematocrit. the last reduction was utter misery. I was close to as miserable as when I had low E2 and low T on a bad transdermal protocol with chrysin added (chrysin is a "naturally based" aromatase inhibitor). It tanked my E2, and I felt most of the symptoms you describe except water retention.</p><p></p><p>It is tempting to try to find a causative scapegoat for all negative symptoms, and if you make the wrong choice using anastrozole you may be in for a world of hurt.</p><p></p><p>And BTW, different guys react at different levels to anastrozole dosing. I take it now, I experience E2 symptoms at relatively low levels by Sensitive LC/MS/MS testing. I am generally OK around 25-30, but mid 30's start having trouble. Anastrozole at only 0.0625mg EOD (that's about 0.21mg per WEEK, less than your proposed single dose) is enough for me to bring E2 into that desired range. It reduces my numbers by around 5-10 points.</p><p></p><p>You'd be playing with fire on several counts:</p><p></p><p>-the non sensitive test tends to read high, so with your number at 29, you are probably not anywhere near high E2 by the numbers, you could even be low.</p><p>-your symptoms could be attributable to many other things</p><p>-0.25 is potentially a very hefty dose</p><p></p><p>And don't change multiple things at once. You asked about starting anastrozole plus increasing test dose. If you do both and things go worse, you won;t necessarily know which caused your problem. Better to change one thing at a time, wait 6-8 weeks, get labs, re-assess.</p></blockquote><p></p>
[QUOTE="Blackhawk, post: 132248, member: 16042"] Your stated symptoms can come from many other things besides high estradiol. for example, how's your hematocrit? How about thyroid? And how long have you waited for steady state after adjusting dosage? If you reduced dosage it is probable you will feel like crap for up to 6-8 weeks until things stabilize. I had to undergo dosage reduction from 150 to 84mg/week spread out over 6 months to try to bring down hematocrit. the last reduction was utter misery. I was close to as miserable as when I had low E2 and low T on a bad transdermal protocol with chrysin added (chrysin is a "naturally based" aromatase inhibitor). It tanked my E2, and I felt most of the symptoms you describe except water retention. It is tempting to try to find a causative scapegoat for all negative symptoms, and if you make the wrong choice using anastrozole you may be in for a world of hurt. And BTW, different guys react at different levels to anastrozole dosing. I take it now, I experience E2 symptoms at relatively low levels by Sensitive LC/MS/MS testing. I am generally OK around 25-30, but mid 30's start having trouble. Anastrozole at only 0.0625mg EOD (that's about 0.21mg per WEEK, less than your proposed single dose) is enough for me to bring E2 into that desired range. It reduces my numbers by around 5-10 points. You'd be playing with fire on several counts: -the non sensitive test tends to read high, so with your number at 29, you are probably not anywhere near high E2 by the numbers, you could even be low. -your symptoms could be attributable to many other things -0.25 is potentially a very hefty dose And don't change multiple things at once. You asked about starting anastrozole plus increasing test dose. If you do both and things go worse, you won;t necessarily know which caused your problem. Better to change one thing at a time, wait 6-8 weeks, get labs, re-assess. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Anastrazole dosage
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