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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Anabolic Steroids: Effect on Muscle, Metabolism and the Heart
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<blockquote data-quote="madman" data-source="post: 191818" data-attributes="member: 13851"><p><strong>Fig. 4 <span style="color: rgb(184, 49, 47)">Potential mechanisms of insulin resistance with chronic anabolic steroid use.</span> Chronic upregulation of S6K1 via activation of PI3K/Akt signaling cascade by AAS may reduce insulin sensitivity due to inhibition of IRS-1 by S6K1 as seen with nutrient overload models. Furthermore, chronic AAS use may lead to an increase in VAT increasing circulating fatty acids and/or inflammatory cytokines causing inhibition of IRS-1 and reducing insulin sensitivity. Aromatisation of testosterone may lead to increasing levels of Estradiol causing IR by binding to insulin and the insulin receptor. </strong></p><p>[ATTACH=full]11938[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 191818, member: 13851"] [B]Fig. 4 [COLOR=rgb(184, 49, 47)]Potential mechanisms of insulin resistance with chronic anabolic steroid use.[/COLOR] Chronic upregulation of S6K1 via activation of PI3K/Akt signaling cascade by AAS may reduce insulin sensitivity due to inhibition of IRS-1 by S6K1 as seen with nutrient overload models. Furthermore, chronic AAS use may lead to an increase in VAT increasing circulating fatty acids and/or inflammatory cytokines causing inhibition of IRS-1 and reducing insulin sensitivity. Aromatisation of testosterone may lead to increasing levels of Estradiol causing IR by binding to insulin and the insulin receptor. [/B] [ATTACH type="full"]11938[/ATTACH] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Anabolic Steroids: Effect on Muscle, Metabolism and the Heart
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