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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Anabolic steroid use can increase heart disease risk
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<blockquote data-quote="madman" data-source="post: 277850" data-attributes="member: 13851"><p>[URL unfurl="true"]https://www.excelmale.com/threads/high-testosterone-levels-impact-on-the-heart.30035/[/URL]</p><p></p><p></p><p><strong>Summary Points</strong></p><p></p><p><em><strong>• Testosterone, the main endogenous active androgen, is used to treat many clinical conditions</strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Testosterone and other androgens are also used by athletes, non athlete weightlifters or bodybuilders to enhance muscle development, strength, and performance and endurance</strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Testosterone at supraphysiological levels <u>increases cardiovascular disease risk, causes myocardial infarction, stroke, high blood pressure, blood clots, and heart failure</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Testosterone affects the cardiovascular system by changing lipid profile, insulin sensitivity, hemostatic mechanisms, sympathetic nervous system, and renin angiotensin-aldosterone system</strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Testosterone activates <u>proinflammatory and redox processes, decreases nitric oxide bioavailability, and stimulates vasoconstrictor signaling pathways</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Testosterone affects the vasculature by <u>interfering with all mechanisms that control vascular function</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>• In the endothelium, testosterone modulates NO, COX-derived metabolites and EDHF release and signaling</strong></em></p><p></p><p><strong><em>• In VSMCs, testosterone modulates ROS generation, expression, and activity of receptors and ion channels</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 277850, member: 13851"] [URL unfurl="true"]https://www.excelmale.com/threads/high-testosterone-levels-impact-on-the-heart.30035/[/URL] [B]Summary Points[/B] [I][B]• Testosterone, the main endogenous active androgen, is used to treat many clinical conditions • Testosterone and other androgens are also used by athletes, non athlete weightlifters or bodybuilders to enhance muscle development, strength, and performance and endurance • Testosterone at supraphysiological levels [U]increases cardiovascular disease risk, causes myocardial infarction, stroke, high blood pressure, blood clots, and heart failure[/U] • Testosterone affects the cardiovascular system by changing lipid profile, insulin sensitivity, hemostatic mechanisms, sympathetic nervous system, and renin angiotensin-aldosterone system • Testosterone activates [U]proinflammatory and redox processes, decreases nitric oxide bioavailability, and stimulates vasoconstrictor signaling pathways[/U] • Testosterone affects the vasculature by [U]interfering with all mechanisms that control vascular function[/U] • In the endothelium, testosterone modulates NO, COX-derived metabolites and EDHF release and signaling[/B][/I] [B][I]• In VSMCs, testosterone modulates ROS generation, expression, and activity of receptors and ion channels[/I][/B] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Anabolic steroid use can increase heart disease risk
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