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Interesting that you have experienced it with all three Enan / Natesto / Xyosten, which I would consider very different in terms of timing.  If your theory is right, one would think Natesto would cause the worst problems for you because of how fast your T drops back to normal on any nasal T.


Have you considered that a spike in histamine could be causing these bouts?  I have been looking into histamine as culprit in early morning awakenings.  Histamine is known to cause symptoms similar to what you are descibing.  I have had some success treating it with anti-histamine, but its still bit of a mystery.


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