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Results A total of 4 RCTs reporting the outcomes after treatment with newer MIST for BPH were identified. Patients undergoing the respective procedures i.e. TURP and Aquablation had greater improvement in urinary domain outcomes: International Prostate Symptom Score, Quality of Life, peak flow rate, and Post Voiding Residual compared to patients undergoing non-respective procedures: UroLift and Rezum. Patients in the UroLift group maintained a higher sexual function domain score compared to TURP but not Aquablation. Our multiple comparison analysis did not reveal a significant difference in urinary and sexual domain scores between patients undergoing UroLift and Rezum at 24 months of follow-up.