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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
AI's and joint pain
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<blockquote data-quote="tareload" data-source="post: 233180"><p>[URL unfurl="true"]https://forums.t-nation.com/t/what-is-trt-and-what-is-not-trt/269828/707[/URL]</p><p></p><p><em></em></p><p><em>Finally, we knew that interleukin 17 (IL17) and the IL17 receptor A (IL17RA) were both therapeutic targets in patients with rheumatoid arthritis,<a href="https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#" target="_blank">24</a> so we determined whether the expression of TCL1A was correlated with the expression of either IL17 or IL17RA in the same 288 lymphoblastoid cell lines. Expression of TCL1A and IL7RA were correlated (r = 0.36; P < 1.9E-10). We then demonstrated in U2OS cells that small interfering RNA knockdown of TCL1A resulted in decreased expression of IL17RA but increased expression of IL17 mRNA (<a href="https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#" target="_blank">Figs 4</a>A and <a href="https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#" target="_blank">4</a>B), while overexpression of TCL1A resulted in increased IL17RA expression and decreased expression of mRNA for the ligand IL17 (<a href="https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#" target="_blank">Figs 4</a>C and <a href="https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#" target="_blank">4</a>D).</em></p></blockquote><p></p>
[QUOTE="tareload, post: 233180"] [URL unfurl="true"]https://forums.t-nation.com/t/what-is-trt-and-what-is-not-trt/269828/707[/URL] [I] Finally, we knew that interleukin 17 (IL17) and the IL17 receptor A (IL17RA) were both therapeutic targets in patients with rheumatoid arthritis,[URL='https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#']24[/URL] so we determined whether the expression of TCL1A was correlated with the expression of either IL17 or IL17RA in the same 288 lymphoblastoid cell lines. Expression of TCL1A and IL7RA were correlated (r = 0.36; P < 1.9E-10). We then demonstrated in U2OS cells that small interfering RNA knockdown of TCL1A resulted in decreased expression of IL17RA but increased expression of IL17 mRNA ([URL='https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#']Figs 4[/URL]A and [URL='https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#']4[/URL]B), while overexpression of TCL1A resulted in increased IL17RA expression and decreased expression of mRNA for the ligand IL17 ([URL='https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#']Figs 4[/URL]C and [URL='https://ascopubs.org/doi/10.1200/JCO.2010.28.5064#']4[/URL]D).[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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