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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Age-Specific Serum Total and Free Estradiol Concentrations in Healthy Men in US Nationally Representative Samples
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<blockquote data-quote="madman" data-source="post: 159638" data-attributes="member: 13851"><p><strong>Purpose:</strong> To report age-specific serum estradiol concentration in nonsmoking, lean US men without comorbidities. We provide concentrations from 30 and 15 to 20 years ago given previously described declines in serum estradiol in US men over time.</p><p></p><p><strong>Methods:</strong> We used data from the Third National Health and Nutrition Examination Survey (NHANES III; 1988 to 1991) and continuous NHANES (1999 to 2004). Serum estradiol and SHBG were previously measured by competitive electrochemiluminescence immunoassays. Free estradiol was estimated from estradiol, SHBG, and albumin. By age, we calculated median concentrations overall and for nonsmoking, lean (body mass index ,25 kg/m2 and waist ,102 cm) men without diabetes, cardiovascular disease, or cancer.</p><p></p><p><strong>Results: </strong><span style="color: rgb(184, 49, 47)"><strong>Overall, respective total estradiol medians for men ages 20 to 39, 40 to 59, and $60 years old were 37.0, 33.9, and 33.5 pg/mL in NHANES III</strong></span><span style="color: rgb(0, 0, 0)"><strong> and 31.3, 30.5, and 27.0 pg/mL in continuous NHANES.</strong></span> <span style="color: rgb(184, 49, 47)"><strong>In nonsmoking, lean men without comorbidities, respective total estradiol medians were 32.0, 32.1, and 32.0 pg/mL in NHANES III </strong></span><span style="color: rgb(0, 0, 0)"><strong>and 29.1, 22.7, and 26.1 pg/mL in continuous NHANES.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>Overall, respective free estradiol medians were 0.82, 0.72, and 0.64 pg/mL in NHANES III</strong></span> <span style="color: rgb(26, 188, 156)"><strong>and 0.67, 0.61, and 0.47 pg/mL in continuous NHANES.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>In nonsmoking, lean men without comorbidities, respective free estradiol medians were 0.64, 0.67, and 0.62 pg/mL in NHANES III</strong></span><span style="color: rgb(26, 188, 156)"><strong> and 0.58, 0.42, and 0.40 pg/mL continuous NHANES.</strong></span></p><p></p><p><strong>Conclusion:</strong> <strong><span style="color: rgb(184, 49, 47)">We report US nationally representative serum estradiol concentrations in healthy men, which could be used for targeting estradiol during testosterone supplementation and for general good health.</span></strong></p><p></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">In conclusion, we assessed the age-specific distributions of total and free estradiol in NHANES III and 1999 to 2004.</span></strong> <span style="color: rgb(0, 0, 0)"><strong>Our goal was to report typical estradiol levels in a nationally representative population of healthy men to support the implementation of clinical guidelines for serum estradiol concentrations for men with symptomatic testosterone deficiency who are candidates for testosterone supplementation, and for men in general for good health.</strong></span> <span style="color: rgb(184, 49, 47)"><strong>With respect to the former use, we envision that consensus guideline developers might need this information.</strong></span> <span style="color: rgb(0, 0, 0)"><strong>With respect to the latter use, clinical consensus would be needed to define the array of estrogen-associated health states that should be considered and how their relative harms and benefits should be included when optimizing target serum estradiol levels for good health in general based on never-smoking, lean men without comorbidities. </strong></span><span style="color: rgb(44, 130, 201)"><strong>Given the recognized racial and ethnic variability in circulating estradiol levels, more work is needed, including by future measurement of estradiol concentrations in existing samples from more recent NHANES surveys, to report with precision population specific estradiol levels. </strong></span></p></blockquote><p></p>
[QUOTE="madman, post: 159638, member: 13851"] [B]Purpose:[/B] To report age-specific serum estradiol concentration in nonsmoking, lean US men without comorbidities. We provide concentrations from 30 and 15 to 20 years ago given previously described declines in serum estradiol in US men over time. [B]Methods:[/B] We used data from the Third National Health and Nutrition Examination Survey (NHANES III; 1988 to 1991) and continuous NHANES (1999 to 2004). Serum estradiol and SHBG were previously measured by competitive electrochemiluminescence immunoassays. Free estradiol was estimated from estradiol, SHBG, and albumin. By age, we calculated median concentrations overall and for nonsmoking, lean (body mass index ,25 kg/m2 and waist ,102 cm) men without diabetes, cardiovascular disease, or cancer. [B]Results: [/B][COLOR=rgb(184, 49, 47)][B]Overall, respective total estradiol medians for men ages 20 to 39, 40 to 59, and $60 years old were 37.0, 33.9, and 33.5 pg/mL in NHANES III[/B][/COLOR][COLOR=rgb(0, 0, 0)][B] and 31.3, 30.5, and 27.0 pg/mL in continuous NHANES.[/B][/COLOR] [COLOR=rgb(184, 49, 47)][B]In nonsmoking, lean men without comorbidities, respective total estradiol medians were 32.0, 32.1, and 32.0 pg/mL in NHANES III [/B][/COLOR][COLOR=rgb(0, 0, 0)][B]and 29.1, 22.7, and 26.1 pg/mL in continuous NHANES.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]Overall, respective free estradiol medians were 0.82, 0.72, and 0.64 pg/mL in NHANES III[/B][/COLOR] [COLOR=rgb(26, 188, 156)][B]and 0.67, 0.61, and 0.47 pg/mL in continuous NHANES.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]In nonsmoking, lean men without comorbidities, respective free estradiol medians were 0.64, 0.67, and 0.62 pg/mL in NHANES III[/B][/COLOR][COLOR=rgb(26, 188, 156)][B] and 0.58, 0.42, and 0.40 pg/mL continuous NHANES.[/B][/COLOR] [B]Conclusion:[/B] [B][COLOR=rgb(184, 49, 47)]We report US nationally representative serum estradiol concentrations in healthy men, which could be used for targeting estradiol during testosterone supplementation and for general good health.[/COLOR][/B] [B][COLOR=rgb(184, 49, 47)]In conclusion, we assessed the age-specific distributions of total and free estradiol in NHANES III and 1999 to 2004.[/COLOR][/B] [COLOR=rgb(0, 0, 0)][B]Our goal was to report typical estradiol levels in a nationally representative population of healthy men to support the implementation of clinical guidelines for serum estradiol concentrations for men with symptomatic testosterone deficiency who are candidates for testosterone supplementation, and for men in general for good health.[/B][/COLOR] [COLOR=rgb(184, 49, 47)][B]With respect to the former use, we envision that consensus guideline developers might need this information.[/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]With respect to the latter use, clinical consensus would be needed to define the array of estrogen-associated health states that should be considered and how their relative harms and benefits should be included when optimizing target serum estradiol levels for good health in general based on never-smoking, lean men without comorbidities. [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]Given the recognized racial and ethnic variability in circulating estradiol levels, more work is needed, including by future measurement of estradiol concentrations in existing samples from more recent NHANES surveys, to report with precision population specific estradiol levels. [/B][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Age-Specific Serum Total and Free Estradiol Concentrations in Healthy Men in US Nationally Representative Samples
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