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Age Management Physician New to the Forum- Happy to Help!
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<blockquote data-quote="efete1" data-source="post: 88209" data-attributes="member: 17047"><p>Metformin is an interesting drug with many uses and benefits. If you have any hint of insulin resistance it's a no brainer for most. However if you have your nutrition, exercise, and hormones dialed in there really is no need to add it. If it's just for longevity only, there may indeed be a benefit but again the trials/studies needed to prove this have not been done. There are some that have concerns about mitochondrial damage from long term use. It may be worth using for 6 months at a time and then stopping for a few months. </p><p>A study titled "Targeting Aging with Metformin," or "TAME" for short, began in 2015, and will be looking at at men and women over the age of 60. It won't conclude for another five years, so we will have to wait and see what it shows in regards to long term use, longevity effects etc.</p><p></p><p>Other options to enhance AMPK, increase longevity etc without any concern for side effects would be the use of Gynostemma, and intermittent fasting. </p><p></p><p>Happy Thanksgiving!</p><p></p><p>Dr. Eric</p></blockquote><p></p>
[QUOTE="efete1, post: 88209, member: 17047"] Metformin is an interesting drug with many uses and benefits. If you have any hint of insulin resistance it's a no brainer for most. However if you have your nutrition, exercise, and hormones dialed in there really is no need to add it. If it's just for longevity only, there may indeed be a benefit but again the trials/studies needed to prove this have not been done. There are some that have concerns about mitochondrial damage from long term use. It may be worth using for 6 months at a time and then stopping for a few months. A study titled "Targeting Aging with Metformin," or "TAME" for short, began in 2015, and will be looking at at men and women over the age of 60. It won't conclude for another five years, so we will have to wait and see what it shows in regards to long term use, longevity effects etc. Other options to enhance AMPK, increase longevity etc without any concern for side effects would be the use of Gynostemma, and intermittent fasting. Happy Thanksgiving! Dr. Eric [/QUOTE]
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