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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Age‐dependent changes in the reproductive axis responsiveness to kisspeptin‐10 administration in healthy men
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<blockquote data-quote="madman" data-source="post: 132914" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">Abstract</span> </strong></p><p></p><p><em>The present study was designed to assess the responsiveness of the hypothalamic-pituitary-gonadal axis to kisspeptin administration with increasing age in men. Human kisspeptin‐10 was administered in a single iv bolus dose (1 µg/kg BW) to healthy adult, middle and advanced-age men. Serial blood samples were collected for 30 min pre‐ and 120 min post‐kisspeptin injection periods at 30‐min interval. Analysis of plasma LH by ELISA showed a significant (p < 0.05) increase after kisspeptin‐10 administration in all groups, whereas plasma testosterone concentration, was significantly elevated (p < 0.05) after kisspeptin‐10 injection only in the adult men group. Present results suggest that in men, the central hypothalamic-pituitary axis remains active and shows responsiveness to kisspeptin stimulation across life. However, Leydig cell responsiveness to kisspeptin‐induced LH decreases with age in men.</em></p><p></p><p></p><p></p><p></p><p></p><p><strong>5 CONCLUSION</strong></p><p><strong></strong></p><p><strong><em>Conclusively, the present study suggests that KP‐10 raises plasma LH secretion in adult, middle and advanced-age men equally. Plasma testosterone concentration of adult-age men is increased by iv bolus administration of KP‐10 while no increase occurs in circulating testosterone concentration of middle‐aged and advanced-age men. <span style="color: rgb(184, 49, 47)">Our findings suggest that in men central hypothalamic-pituitary axis remains active and shows responsiveness to KP‐10 across the life, but Leydig cell responsiveness to gonadotropin decreases with age.</span> These results will provide a great insight into the understanding of kisspeptin physiology in the reproductive system.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 132914, member: 13851"] [B][COLOR=rgb(184, 49, 47)]Abstract[/COLOR] [/B] [I]The present study was designed to assess the responsiveness of the hypothalamic-pituitary-gonadal axis to kisspeptin administration with increasing age in men. Human kisspeptin‐10 was administered in a single iv bolus dose (1 µg/kg BW) to healthy adult, middle and advanced-age men. Serial blood samples were collected for 30 min pre‐ and 120 min post‐kisspeptin injection periods at 30‐min interval. Analysis of plasma LH by ELISA showed a significant (p < 0.05) increase after kisspeptin‐10 administration in all groups, whereas plasma testosterone concentration, was significantly elevated (p < 0.05) after kisspeptin‐10 injection only in the adult men group. Present results suggest that in men, the central hypothalamic-pituitary axis remains active and shows responsiveness to kisspeptin stimulation across life. However, Leydig cell responsiveness to kisspeptin‐induced LH decreases with age in men.[/I] [B]5 CONCLUSION [I]Conclusively, the present study suggests that KP‐10 raises plasma LH secretion in adult, middle and advanced-age men equally. Plasma testosterone concentration of adult-age men is increased by iv bolus administration of KP‐10 while no increase occurs in circulating testosterone concentration of middle‐aged and advanced-age men. [COLOR=rgb(184, 49, 47)]Our findings suggest that in men central hypothalamic-pituitary axis remains active and shows responsiveness to KP‐10 across the life, but Leydig cell responsiveness to gonadotropin decreases with age.[/COLOR] These results will provide a great insight into the understanding of kisspeptin physiology in the reproductive system.[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Age‐dependent changes in the reproductive axis responsiveness to kisspeptin‐10 administration in healthy men
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