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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advise for 40s guy
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<blockquote data-quote="BadassBlues" data-source="post: 243429" data-attributes="member: 38526"><p>Hi Sasha,</p><p></p><p>This is an interesting thread; you are now an official member of the "club". The club is made up of aging men looking to regain their youthful vigor. I too am a member, although just a bit older...<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink ;)" loading="lazy" data-shortname=";)" /></p><p></p><p>Testosterone is only a part of the equation, an important one, but not necessarily the silver bullet. Overall health, mental and emotional state, lifestyle, bad habits and other factors are key factors.</p><p></p><p>One thing I have determined about TRT is that exogenous testosterone alone has a propensity to alter emotional state. For lack of a better way to put it, it deadens emotional joy. I have experienced this, and years of reading this same story from other guys has solidified my opinion. </p><p></p><p>When Exo T is introduced to the body the pituitary stops making LH. The signal is broken due to the feedback loop being shut down. There are LH receptors located in other parts of the body and studies have shown a direct correlation to the central nervous system:</p><p></p><h3>Neural actions of luteinizing hormone and human chorionic gonadotropin</h3><p><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Lei+ZM&cauthor_id=11394198" target="_blank">Z M Lei</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11394198/#affiliation-1" target="_blank">1</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Rao+CV&cauthor_id=11394198" target="_blank">C V Rao</a></p><p>Affiliations expand</p><ul> <li data-xf-list-type="ul">PMID: <strong>11394198</strong></li> <li data-xf-list-type="ul">DOI: <a href="https://doi.org/10.1055/s-2001-13917" target="_blank">10.1055/s-2001-13917</a></li> </ul><h3>Abstract</h3><p>Luteinizing hormone (LH) and its homologue, human chorionic gonadotropin (hCG), are able to elicit multiple effects in the central nervous system (CNS) through binding to their receptors. Specific receptors for LH/hCG have been identified in the hippocampus, dentate gyrus, hypothalamus, cortex, brain stem, area postrema, cerebellum, choroid plexus, ependymal cells, glial cells, neural retina, pituitary gland, and neuron processes of the spinal cord. Neurotropic effects of LH and hCG have been demonstrated in fetal rat brain, where the expression of LH/hCG receptors is developmentally regulated. Administration of hCG has been found to be beneficial in restoration of transected spinal cord function in rats. In adult rat brain, LH and hCG are involved in the feedback regulation of synthesis and secretion of gonadotropin-releasing hormone (GnRH) in the hypothalamus and LH in the pituitary gland. LH and hCG also induce several behavioral and other changes that are associated with the hippocampus, which contains the highest density of LH/hCG receptors. Many of the behavioral changes induced by hCG in rats parallel those in pregnant women. Some of these behavioral effects are correlated with changes of eicosanoid metabolism induced by LH and hCG in the brain. The LH/hCG receptors present in the choroid plexus, brain vessels, and perihypophyseal vascular complex may be involved in the modulation of transport of LH, hCG, and GnRH into the CNS. <strong><em><u>Thus, the CNS is one of the specific target tissues for LH and hCG, by which LH/hCG act as pleiotropic hormones that regulate several reproduction-related as well as reproduction-nonrelated functions in the CNS.</u></em></strong></p><p></p><p> In short, the lack of LH signaling to other parts of the body can <em>in theory </em>create a deficit in other functioning. Anyone who has ever used HCG can attest to the feeling of well being after injection. </p><p></p><p>IMHO... TRT without HCG as an adjunct is only half of the process.</p><p></p><p>As I mentioned though, other factors are also involved;</p><p></p><p>1. Drug and alcohol use.</p><p>2. Porn.</p><p>3. Nutrition.</p><p>4. Poor mental and emotional state, depression.</p><p>5. Overall lifestyle.</p><p></p><p>One of the best things I have ever done for myself was to learn to meditate and incorporate it into my daily routine. I also have stopped obsessing over things and just keep looking for the sunshine. I am not 20 anymore, but now I have days where I still feel like I am...</p><p></p><p>Just my 2 cents from a club member...<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink ;)" loading="lazy" data-shortname=";)" /></p></blockquote><p></p>
[QUOTE="BadassBlues, post: 243429, member: 38526"] Hi Sasha, This is an interesting thread; you are now an official member of the "club". The club is made up of aging men looking to regain their youthful vigor. I too am a member, although just a bit older...;) Testosterone is only a part of the equation, an important one, but not necessarily the silver bullet. Overall health, mental and emotional state, lifestyle, bad habits and other factors are key factors. One thing I have determined about TRT is that exogenous testosterone alone has a propensity to alter emotional state. For lack of a better way to put it, it deadens emotional joy. I have experienced this, and years of reading this same story from other guys has solidified my opinion. When Exo T is introduced to the body the pituitary stops making LH. The signal is broken due to the feedback loop being shut down. There are LH receptors located in other parts of the body and studies have shown a direct correlation to the central nervous system: [HEADING=2]Neural actions of luteinizing hormone and human chorionic gonadotropin[/HEADING] [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Lei+ZM&cauthor_id=11394198']Z M Lei[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/11394198/#affiliation-1']1[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Rao+CV&cauthor_id=11394198']C V Rao[/URL] Affiliations expand [LIST] [*]PMID: [B]11394198[/B] [*]DOI: [URL='https://doi.org/10.1055/s-2001-13917']10.1055/s-2001-13917[/URL] [/LIST] [HEADING=2]Abstract[/HEADING] Luteinizing hormone (LH) and its homologue, human chorionic gonadotropin (hCG), are able to elicit multiple effects in the central nervous system (CNS) through binding to their receptors. Specific receptors for LH/hCG have been identified in the hippocampus, dentate gyrus, hypothalamus, cortex, brain stem, area postrema, cerebellum, choroid plexus, ependymal cells, glial cells, neural retina, pituitary gland, and neuron processes of the spinal cord. Neurotropic effects of LH and hCG have been demonstrated in fetal rat brain, where the expression of LH/hCG receptors is developmentally regulated. Administration of hCG has been found to be beneficial in restoration of transected spinal cord function in rats. In adult rat brain, LH and hCG are involved in the feedback regulation of synthesis and secretion of gonadotropin-releasing hormone (GnRH) in the hypothalamus and LH in the pituitary gland. LH and hCG also induce several behavioral and other changes that are associated with the hippocampus, which contains the highest density of LH/hCG receptors. Many of the behavioral changes induced by hCG in rats parallel those in pregnant women. Some of these behavioral effects are correlated with changes of eicosanoid metabolism induced by LH and hCG in the brain. The LH/hCG receptors present in the choroid plexus, brain vessels, and perihypophyseal vascular complex may be involved in the modulation of transport of LH, hCG, and GnRH into the CNS. [B][I][U]Thus, the CNS is one of the specific target tissues for LH and hCG, by which LH/hCG act as pleiotropic hormones that regulate several reproduction-related as well as reproduction-nonrelated functions in the CNS.[/U][/I][/B] In short, the lack of LH signaling to other parts of the body can [I]in theory [/I]create a deficit in other functioning. Anyone who has ever used HCG can attest to the feeling of well being after injection. IMHO... TRT without HCG as an adjunct is only half of the process. As I mentioned though, other factors are also involved; 1. Drug and alcohol use. 2. Porn. 3. Nutrition. 4. Poor mental and emotional state, depression. 5. Overall lifestyle. One of the best things I have ever done for myself was to learn to meditate and incorporate it into my daily routine. I also have stopped obsessing over things and just keep looking for the sunshine. I am not 20 anymore, but now I have days where I still feel like I am... Just my 2 cents from a club member...;) [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advise for 40s guy
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