ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice on low dose daily testosterone
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 202579" data-attributes="member: 13851"><p>Regarding aqueous testosterone suspension, although there would be rapid absorption of the aqueous vehicle, the crystals of T depending on the particle size (human/veterinary grade) may very well behave like small implants which would be more slowly absorbed from the tissues although it is much faster acting than an esterified T such as (propionate).</p><p></p><p>With T base (oil/no ester) it would most likely be absorbed/degraded more quickly.</p><p></p><p></p><p></p><p></p><p><em><strong>*Pulsatile secretion of a hormone refers to the intermittent secretion of the hormone in a burst-like or episodic manner rather than constantly, with the frequency varying from minutes to hours, determined in part by the half-life of the hormone.</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*T levels in a healthy male follow a diurnal variation and circadian rhythm, with levels highest early in the morning and subsequently declining as the day progresses, as a direct result of pulsatile LH secretion (3).</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><strong><em>*<u>A sustained steady-state level of T, however, differs from the normal circadian physiology of a healthy individual</u>.</em></strong></p><p></p><p></p><p><em><strong>*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has two or three discrete peaks (“pulses”) of testosterone <u>provoked by LH secretions that occur on average every 2 hours</u>. <u>A maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h)</u>. The nadir (trough) between doses correlates well with pre-treatment endogenous levels at diagnosis.</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The unique, pulsatile, pharmacokinetic profile is believed to have limited impact on the HPG axis with <u>significant trough time preserving luteinizing hormone (LH), follicle-stimulating hormone (FSH), endogenous testosterone production, and sperm counts, while also limiting excess RBC production, estradiol, DHT and PSA in clinical trials</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><strong><em>*In between NATESTO® doses, all patients in the phase 3 study maintained their natural testosterone at the same levels they had prior to entry into the study, indicating that NATESTO® does not suppress natural testosterone production. Based on the data, Acerus believes that the mechanism of action of NATESTO® is unique whereby <u>the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production</u>.</em></strong></p><p></p><p></p><p></p><p></p><p>Even then keep in mind that Natesto is dosed 2-3 times daily which results in 2-3 discrete peaks (achieved max TT level is around 800 ng/dL) which are well below supra-physiological.</p><p></p><p>[ATTACH=full]14658[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 202579, member: 13851"] Regarding aqueous testosterone suspension, although there would be rapid absorption of the aqueous vehicle, the crystals of T depending on the particle size (human/veterinary grade) may very well behave like small implants which would be more slowly absorbed from the tissues although it is much faster acting than an esterified T such as (propionate). With T base (oil/no ester) it would most likely be absorbed/degraded more quickly. [I][B]*Pulsatile secretion of a hormone refers to the intermittent secretion of the hormone in a burst-like or episodic manner rather than constantly, with the frequency varying from minutes to hours, determined in part by the half-life of the hormone. *T levels in a healthy male follow a diurnal variation and circadian rhythm, with levels highest early in the morning and subsequently declining as the day progresses, as a direct result of pulsatile LH secretion (3). [/B][/I] [B][I]*[U]A sustained steady-state level of T, however, differs from the normal circadian physiology of a healthy individual[/U].[/I][/B] [I][B]*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has two or three discrete peaks (“pulses”) of testosterone [U]provoked by LH secretions that occur on average every 2 hours[/U]. [U]A maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h)[/U]. The nadir (trough) between doses correlates well with pre-treatment endogenous levels at diagnosis. *The unique, pulsatile, pharmacokinetic profile is believed to have limited impact on the HPG axis with [U]significant trough time preserving luteinizing hormone (LH), follicle-stimulating hormone (FSH), endogenous testosterone production, and sperm counts, while also limiting excess RBC production, estradiol, DHT and PSA in clinical trials[/U]. [/B][/I] [B][I]*In between NATESTO® doses, all patients in the phase 3 study maintained their natural testosterone at the same levels they had prior to entry into the study, indicating that NATESTO® does not suppress natural testosterone production. Based on the data, Acerus believes that the mechanism of action of NATESTO® is unique whereby [U]the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production[/U].[/I][/B] Even then keep in mind that Natesto is dosed 2-3 times daily which results in 2-3 discrete peaks (achieved max TT level is around 800 ng/dL) which are well below supra-physiological. [ATTACH type="full"]14658[/ATTACH] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice on low dose daily testosterone
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top