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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice on low dose daily testosterone
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<blockquote data-quote="madman" data-source="post: 194146" data-attributes="member: 13851"><p>Topical gel formulations achieve a sustained mid-normal T level with a once-daily application (8). <strong><u>While the topical gel results in less fluctuation of T levels between dosing intervals when compared to IM T, the sustained T levels result in inhibition of HPG axis activity</u> (9). </strong>The inhibition of HPG axis activity is evidenced by the nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration (9).</p><p></p><p><em><u>Nasal administration of T (4.5% testosterone nasal gel, Natesto) allows for rapid absorption through the nasal mucosa such that serum T levels reach a peak concentration in ∼40 min. <strong>Once in the circulation, the T is quickly metabolized, with a return to near baseline T levels in 3–6 h</strong></u><strong> (11). <u>Therefore, multiple administrations of nasal T throughout the day (three times daily) maintain normal mean serum T levels over 24 h</u>. <u>The fluctuations in T levels potentially minimize the duration of exposure to exogenous T that is suppressive to the HPG axis, compared to other available T therapies</u>.</strong></em></p><p><em></em></p><p><em></em></p><p><em>Endocrine systems are regulated dynamically in response to positive or negative stimuli within a homeostatic environment. <strong><u>Modalities of T therapy evolved to extend the dosing interval and maintain sustained “steady-state” T levels. Long-acting TTh can inhibit the HPG axis, which in turn suppresses pituitary LH and FSH secretion, reducing circulating levels of LH and FSH and endogenous T production</u></strong></em><strong><em> </em></strong></p><p><strong><em></em></strong></p><p><strong><em><u>Short-acting T therapy, consisting of several doses of T with a shorter half-life throughout the day, minimizes inhibition of the HPG axis and reduces the impairment of spermatogenesis</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 194146, member: 13851"] Topical gel formulations achieve a sustained mid-normal T level with a once-daily application (8). [B][U]While the topical gel results in less fluctuation of T levels between dosing intervals when compared to IM T, the sustained T levels result in inhibition of HPG axis activity[/U] (9). [/B]The inhibition of HPG axis activity is evidenced by the nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration (9). [I][U]Nasal administration of T (4.5% testosterone nasal gel, Natesto) allows for rapid absorption through the nasal mucosa such that serum T levels reach a peak concentration in ∼40 min. [B]Once in the circulation, the T is quickly metabolized, with a return to near baseline T levels in 3–6 h[/B][/U][B] (11). [U]Therefore, multiple administrations of nasal T throughout the day (three times daily) maintain normal mean serum T levels over 24 h[/U]. [U]The fluctuations in T levels potentially minimize the duration of exposure to exogenous T that is suppressive to the HPG axis, compared to other available T therapies[/U].[/B] Endocrine systems are regulated dynamically in response to positive or negative stimuli within a homeostatic environment. [B][U]Modalities of T therapy evolved to extend the dosing interval and maintain sustained “steady-state” T levels. Long-acting TTh can inhibit the HPG axis, which in turn suppresses pituitary LH and FSH secretion, reducing circulating levels of LH and FSH and endogenous T production[/U][/B][/I][B][I] [U]Short-acting T therapy, consisting of several doses of T with a shorter half-life throughout the day, minimizes inhibition of the HPG axis and reduces the impairment of spermatogenesis[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice on low dose daily testosterone
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