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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice on low dose daily testosterone
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<blockquote data-quote="sammmy" data-source="post: 193983" data-attributes="member: 38594"><p>Absorption time matters if you want to simulate Natesto with fast peaks and fast valleys. This reduces suppression or testosterone production in the body. If all of your testosterone comes from TRT, you would not care of that - you are already suppressed.</p><p></p><p>TNE (unmodified testosterone suspension) is not in current use, probably because it is absorbed too fast, requiring too many injections to maintain testosterone levels. Also, its absorption will depend on the size of the testosterone crystals in the suspension, which is hard to control, making it unreliable. Last, testo crystal suspensions in water cause local reactions lasting for days, which are less frequent with oil solutions: <a href="https://en.wikipedia.org/wiki/Testosterone_phenylacetate" target="_blank">Wikipedia - testosterone phenylacetate water suspension</a></p><p></p><p>I could not find a contemporary pharmacokinetic study for TNE in humans. Probably these were done in the early years of discovering testosterone and then TNE was replaced by the esters in oil because of the above arguments. Everywhere, there is cited the same dumb statement that "unmodified testosterone has a half-life of only 10 minutes and would have to be injected very frequently". However this is surely talking about the half-life in blood. When the suspension is injected in the muscle, it forms a water depot and it is not released instantly into circulation. By the way, the half-life of testosterone propionate in blood is also about 10 minutes because it is converted to pure testosterone very fast. The prolonged half-life of the propionate is actually due to</p><p>the oil depot in the muscle from which it is slowly released with the oil.</p></blockquote><p></p>
[QUOTE="sammmy, post: 193983, member: 38594"] Absorption time matters if you want to simulate Natesto with fast peaks and fast valleys. This reduces suppression or testosterone production in the body. If all of your testosterone comes from TRT, you would not care of that - you are already suppressed. TNE (unmodified testosterone suspension) is not in current use, probably because it is absorbed too fast, requiring too many injections to maintain testosterone levels. Also, its absorption will depend on the size of the testosterone crystals in the suspension, which is hard to control, making it unreliable. Last, testo crystal suspensions in water cause local reactions lasting for days, which are less frequent with oil solutions: [URL='https://en.wikipedia.org/wiki/Testosterone_phenylacetate']Wikipedia - testosterone phenylacetate water suspension[/URL] I could not find a contemporary pharmacokinetic study for TNE in humans. Probably these were done in the early years of discovering testosterone and then TNE was replaced by the esters in oil because of the above arguments. Everywhere, there is cited the same dumb statement that "unmodified testosterone has a half-life of only 10 minutes and would have to be injected very frequently". However this is surely talking about the half-life in blood. When the suspension is injected in the muscle, it forms a water depot and it is not released instantly into circulation. By the way, the half-life of testosterone propionate in blood is also about 10 minutes because it is converted to pure testosterone very fast. The prolonged half-life of the propionate is actually due to the oil depot in the muscle from which it is slowly released with the oil. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice on low dose daily testosterone
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