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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice on low dose daily testosterone
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<blockquote data-quote="sammmy" data-source="post: 193940" data-attributes="member: 38594"><p>To imitate Natesto, the testosterone suspension has to be absorbed fast in 30mins - 2 hours. It is not clear if intramuscular or subcutaneous injection can achieve that.</p><p></p><p>I can't find any pharmacokinetic data on testosterone suspension, except one study in horses that injected a huge dose for horses that persisted for 30 days:</p><p></p><p></p><p></p><p>If that fails, the Wikipedia article <a href="https://en.wikipedia.org/wiki/Pharmacokinetics_of_testosterone" target="_blank">Pharmacokinetics of testosterone</a> suggests that fast absorption is obtained with:</p><ul> <li data-xf-list-type="ul">oral testosterone undecanoate. It is taken several times a day like Natesto.</li> <li data-xf-list-type="ul"><a href="https://academic.oup.com/jcem/article/81/10/3654/2650025" target="_blank">sublingual testosterone Testoral</a>. This was absorption enhanced by complexing with cyclodextrine around 1996 but is no longer available. The idea of Natesto is actually a remake of Testoral. Some compounding pharmacies have testosterone drops or troches but it is rather unclear how much of testosterone is absorbed without special enhancers like cyclodextrine.</li> <li data-xf-list-type="ul">scrotal application of testosterone gel or cream. The dose will have to be higher than nasal/sublingual and there are claims that scrotal leads to higher DHT, compared to transdermal or sublingual/intranasal.</li> </ul><p></p><p>I am not at all convinced in the popular claim that scrotal application leads to higher DHT than transdermal or sublingual/nasal. The sublingual Testoral link above shows DHT increases by a factor of 6 at the peak 30 mins after administration. However, in this <a href="https://eje.bioscientifica.com/view/journals/eje/153/2/1530317.xml" target="_blank">scrotal vs transdermal vs patch</a> study, 2 hours after gel application, DHT increased by a factor of 6.5 in the scrotal group and by a factor of 5 in the transdermal group. So in terms of keeping DHT low, these studies show no difference between scrotal, sublingual, and transdermal modes of administration. I looked for DHT studies for Natesto but could not find any - it should be similar to sublingual Testoral though.</p></blockquote><p></p>
[QUOTE="sammmy, post: 193940, member: 38594"] To imitate Natesto, the testosterone suspension has to be absorbed fast in 30mins - 2 hours. It is not clear if intramuscular or subcutaneous injection can achieve that. I can't find any pharmacokinetic data on testosterone suspension, except one study in horses that injected a huge dose for horses that persisted for 30 days: If that fails, the Wikipedia article [URL='https://en.wikipedia.org/wiki/Pharmacokinetics_of_testosterone']Pharmacokinetics of testosterone[/URL] suggests that fast absorption is obtained with: [LIST] [*]oral testosterone undecanoate. It is taken several times a day like Natesto. [*][URL='https://academic.oup.com/jcem/article/81/10/3654/2650025']sublingual testosterone Testoral[/URL]. This was absorption enhanced by complexing with cyclodextrine around 1996 but is no longer available. The idea of Natesto is actually a remake of Testoral. Some compounding pharmacies have testosterone drops or troches but it is rather unclear how much of testosterone is absorbed without special enhancers like cyclodextrine. [*]scrotal application of testosterone gel or cream. The dose will have to be higher than nasal/sublingual and there are claims that scrotal leads to higher DHT, compared to transdermal or sublingual/intranasal. [/LIST] I am not at all convinced in the popular claim that scrotal application leads to higher DHT than transdermal or sublingual/nasal. The sublingual Testoral link above shows DHT increases by a factor of 6 at the peak 30 mins after administration. However, in this [URL='https://eje.bioscientifica.com/view/journals/eje/153/2/1530317.xml']scrotal vs transdermal vs patch[/URL] study, 2 hours after gel application, DHT increased by a factor of 6.5 in the scrotal group and by a factor of 5 in the transdermal group. So in terms of keeping DHT low, these studies show no difference between scrotal, sublingual, and transdermal modes of administration. I looked for DHT studies for Natesto but could not find any - it should be similar to sublingual Testoral though. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice on low dose daily testosterone
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