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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
advice on getting dialed in
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<blockquote data-quote="trtthings" data-source="post: 189117" data-attributes="member: 41094"><p>It's not a corticosteroid and I hadn't heard of the effect on cortisol. The problem is that most of the studies with low dose naltrexone have been done with people with autoimmune diseases and they haven't so far focused on cortisol. </p><p></p><p>Here's one study for naltrexone at a more conventional dose: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449011/" target="_blank">Naltrexone effects on cortisol secretion in women and men in relation to a family history of alcoholism: Studies from the Oklahoma Family Health Patterns Project</a></p><p></p><p>Markedly increases cortisol in women but less but still noticeable in men. This is 50mg though - LDN users typically use between 3 - 4.5mg (and start even lower and bump it slowly until they find the sweet spot). The effects might be way different.</p><p></p><p>I find it an interesting drug though, and I agree you don't want to mess with things unless things are already messed up, but what I've heard from doctors is that it's a harmless drug and nobody's ever gotten worse from taking it. </p><p></p><p>The only other thing I know of that I've heard some say reduces brainfog (at least for hypothyroid people) is thyroid medication including T3. </p><p></p><p>It's interesting that you can find studies that show that testosterone increases T4 -> T3 conversion, whereas E2 has the opposite effect.</p></blockquote><p></p>
[QUOTE="trtthings, post: 189117, member: 41094"] It's not a corticosteroid and I hadn't heard of the effect on cortisol. The problem is that most of the studies with low dose naltrexone have been done with people with autoimmune diseases and they haven't so far focused on cortisol. Here's one study for naltrexone at a more conventional dose: [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449011/"]Naltrexone effects on cortisol secretion in women and men in relation to a family history of alcoholism: Studies from the Oklahoma Family Health Patterns Project[/URL] Markedly increases cortisol in women but less but still noticeable in men. This is 50mg though - LDN users typically use between 3 - 4.5mg (and start even lower and bump it slowly until they find the sweet spot). The effects might be way different. I find it an interesting drug though, and I agree you don't want to mess with things unless things are already messed up, but what I've heard from doctors is that it's a harmless drug and nobody's ever gotten worse from taking it. The only other thing I know of that I've heard some say reduces brainfog (at least for hypothyroid people) is thyroid medication including T3. It's interesting that you can find studies that show that testosterone increases T4 -> T3 conversion, whereas E2 has the opposite effect. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
advice on getting dialed in
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