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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice/help for high shbg guy
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<blockquote data-quote="madman" data-source="post: 210818" data-attributes="member: 13851"><p>[URL unfurl="true"]https://tru-t.org/[/URL]</p><p></p><p>The new dynamic model leads to the reconsideration of several dogmas related to testosterone's binding to SHBG and has important physiologic and clinical implications.</p><p><strong></strong></p><p><strong><em>*First, the fraction of circulating testosterone that is free is substantially greater (2.9±0.4%)</em></strong><em> <strong>than has been generally assumed (% cFTV 1.5±0.4%)</strong>.</em></p><p><em></em></p><p><em><strong>*Second, <u>percent FT is not significantly related to total testosterone over a wide range of total testosterone concentrations</u>. However, the percent FT declines as SHBG concentrations increase, although it does not decline as precipitously as predicted by Vermeulen's model. <u>Due to the allostery between the two binding sites, SHBG is able to regulate FT levels in a much larger dynamic range</u>.</strong></em></p><p></p><p></p><p>Key points:</p><p></p><p><strong>EAM (cFTZ) SHBG: T binding</strong></p><p><strong></strong></p><p><strong><em>*</em></strong><em><strong>Intra-dimer complex allostery suggests that<u> SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Indeed, it was found that percent FT calculated using the new model <u>changed very modestly over a wide range of total testosterone concentrations</u>.</strong></em></p><p></p><p><strong><em>*Due to the allostery between the two binding sites, <u>SHBG is able to regulate FT levels in a much larger dynamic range</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 210818, member: 13851"] [URL unfurl="true"]https://tru-t.org/[/URL] The new dynamic model leads to the reconsideration of several dogmas related to testosterone's binding to SHBG and has important physiologic and clinical implications. [B] [I]*First, the fraction of circulating testosterone that is free is substantially greater (2.9±0.4%)[/I][/B][I] [B]than has been generally assumed (% cFTV 1.5±0.4%)[/B]. [B]*Second, [U]percent FT is not significantly related to total testosterone over a wide range of total testosterone concentrations[/U]. However, the percent FT declines as SHBG concentrations increase, although it does not decline as precipitously as predicted by Vermeulen's model. [U]Due to the allostery between the two binding sites, SHBG is able to regulate FT levels in a much larger dynamic range[/U].[/B][/I] Key points: [B]EAM (cFTZ) SHBG: T binding [I]*[/I][/B][I][B]Intra-dimer complex allostery suggests that[U] SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated[/U]. *Indeed, it was found that percent FT calculated using the new model [U]changed very modestly over a wide range of total testosterone concentrations[/U].[/B][/I] [B][I]*Due to the allostery between the two binding sites, [U]SHBG is able to regulate FT levels in a much larger dynamic range[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice/help for high shbg guy
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