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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice/help for high shbg guy
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<blockquote data-quote="madman" data-source="post: 210817" data-attributes="member: 13851"><p>Sure.....if you are one that falls under the 2% of Caucasians that genetically have one of the 2 SHBG polymorphisms which have been described to have to affect T: SHBG binding.</p><p></p><p>I am not buying into this stickier than others SHBG affecting FT levels drastically!</p><p></p><p>Again the only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p>I would not rely upon the piss poor direct immunoassays which are known to be inaccurate let alone the older outdated cFTV when testing FT especially in <strong><em>cases of altered SHBG!</em></strong></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://tru-t.org/[/URL]</p><p></p><p><strong><u>TruT model</u>: 98% of Caucasians (<u>wild type SHBG</u>)</strong></p><p><strong></strong></p><p><strong><em>*The current algorithm and the experimental data reported here were generated using <u>wild-type SHBG which is present in nearly 98% of Caucasians</u>. Genome-wide association studies have revealed several SHBG polymorphisms, two of which have been reported to affect testosterone binding to SHBG (28). Therefore, in the future, the algorithms may include a term for the SHBG genotype.</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>*Relation between Percent FT with Total Testosterone and SHBG. <u>Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated</u>. I<u>ndeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations</u>. In contrast, Vermeulen's equation suggests a negative relation between percent FT and total testosterone. <u>Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline in contrast to the marked decline in percent FT calculated using Vermeulen's equation</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 210817, member: 13851"] Sure.....if you are one that falls under the 2% of Caucasians that genetically have one of the 2 SHBG polymorphisms which have been described to have to affect T: SHBG binding. I am not buying into this stickier than others SHBG affecting FT levels drastically! Again the only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best). I would not rely upon the piss poor direct immunoassays which are known to be inaccurate let alone the older outdated cFTV when testing FT especially in [B][I]cases of altered SHBG![/I][/B] [URL unfurl="true"]https://tru-t.org/[/URL] [B][U]TruT model[/U]: 98% of Caucasians ([U]wild type SHBG[/U]) [I]*The current algorithm and the experimental data reported here were generated using [U]wild-type SHBG which is present in nearly 98% of Caucasians[/U]. Genome-wide association studies have revealed several SHBG polymorphisms, two of which have been reported to affect testosterone binding to SHBG (28). Therefore, in the future, the algorithms may include a term for the SHBG genotype. *Relation between Percent FT with Total Testosterone and SHBG. [U]Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated[/U]. I[U]ndeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations[/U]. In contrast, Vermeulen's equation suggests a negative relation between percent FT and total testosterone. [U]Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline in contrast to the marked decline in percent FT calculated using Vermeulen's equation[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice/help for high shbg guy
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